1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt
(Synonyms: 18) 目录号 : GC684851,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt（18:1 PA；DOPA）是一种阴离子脂质，可用于制备脂质体、胶束和人工膜。
Cas No.:108392-02-5
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (18:1 PA; DOPA) is an anionic lipid that can be used to prepare liposomes, micelles, and artificial membranes[1]. 1,2-Dioleoyl-sn-glycero-3-phosphate is a phospholipid containing the long-chain fatty acid oleic acid inserted at the sn-1 and sn-2 positions[2]. 1,2-Dioleoyl-sn-glycero-3-phosphate is one of the major phosphatidic acid (PA) species in most tissues and cells[3]. 1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt can be used to prepare Zol-Ca composite nanoparticle formulations to improve the delivery and enhance the distribution of Zol in mouse tumor models[4]. Calcium phosphate (CaP)-coated DOPA liposomes have good biomembrane staining ability[5].
References:
[1] Siepi E. Mechanism of amphoteric liposomes & application for siRNA delivery[D]. Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Diss., 2010, 2010.
[2] Rouet‐Mayer M A, Valentova O, Simond‐Côte E, et al. Critical analysis of phospholipid hydrolyzing activities in ripening tomato fruits. Study by spectrofluorimetry and high‐performance liquid chromatography[J]. Lipids, 1995, 30(8): 739-746.
[3] Hoshino F, Sakane F. Polyunsaturated fatty acid-containing phosphatidic acids selectively interact with L-lactate dehydrogenase A and induce its secondary structural change and inactivation[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(10): 158768.
[4] Li X, Naguib Y W, Valdes S, et al. Reverse Microemulsion-Based Synthesis of (Bis) phosphonate–Metal Materials with Controllable Physical Properties: An Example Using Zoledronic Acid–Calcium Complexes[J]. ACS applied materials & interfaces, 2017, 9(16): 14478-14489.
[5] Berti I R, Dell’Arciprete M L, Dittler M L, et al. Delivery of fluorophores by calcium phosphate-coated nanoliposomes and interaction with Staphylococcus aureus biofilms[J]. Colloids and Surfaces B: Biointerfaces, 2016, 142: 214-222.
1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt（18:1 PA；DOPA）是一种阴离子脂质，可用于制备脂质体、胶束和人工膜[1]。1,2-Dioleoyl-sn-glycero-3-phosphate是一种磷脂，含有插入sn-1和sn-2位置的长链脂肪酸油酸[2]。1,2-Dioleoyl-sn-glycero-3-phosphate是大多数组织和细胞中的主要磷脂酸（PA）种类之一[3]。1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt可用于制备Zol-Ca复合纳米颗粒制剂，以改善Zol在小鼠肿瘤模型中的递送并增强其分布[4]。磷酸钙（CaP）包被的DOPA脂质体，具有良好的生物膜染色能力[5]。
| Cas No. | 108392-02-5 | SDF | Download SDF |
| 别名 | 18 | ||
| 分子式 | C39H72NaO8P | 分子量 | 722.95 |
| 溶解度 | Methanol : 10 mg/mL (13.83 mM; Need ultrasonic) | 储存条件 | Store at -20°C, away from moisture and light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3832 mL | 6.9161 mL | 13.8322 mL |
| 5 mM | 0.2766 mL | 1.3832 mL | 2.7664 mL |
| 10 mM | 0.1383 mL | 0.6916 mL | 1.3832 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet