1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. The compound features the same diacylglycerol stereochemistry as that of the natural compound. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.^1,2,3

1.MacDonald, R.C., Rakhmanova, V.A., Choi, K.L., et al.O-ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum-compatible DNA transfection agentJ. Pharm. Sci.88(9)896-904(1999) 2.Misra, S.K., Biswas, J., Kondaiah, P., et al.Gene transfection in high serum levels: Case studies with new cholesterol based cationic gemini lipidsPLoS One8(7)e68305(2013) 3.Chen, Y., Sun, J., Lu, Y., et al.Complexes containing cationic and anionic pH-sensitive liposomes: Comparative study of factors influencing plasmid DNA gene delivery to tumorsInt. J. Nanomedicine81573-1593(2013)