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1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) Sale

(Synonyms: 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA) 目录号 : GC41825

1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)(16:0/16:0-PA)是一种磷脂,含有插入到sn-1和sn-2位置的长链(16:0)棕榈酸,能够用于制备脂质体、胶束和人工膜。

1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) Chemical Structure

Cas No.:169051-60-9

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Sample solution is provided at 25 µL, 10mM.

Description

1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (16:0/16:0-PA) is a phospholipid containing long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions, which can be used to prepare liposomes, micelles and artificial membranes[1, 2]. During retinoic acid and serum starvation-induced neuronal differentiation, diacylglycerol kinase z (DGKz) in mouse neuroblastoma Neuro-2a cells can specifically produce 1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]. 1,2-Dipalmitoyl-sn-glycero-3-phosphate can bind to α-synuclein (α-syn)[4].

References:
[1] Sierra-Valdez F J, Forero-Quintero L S, Zapata-Morin P A, et al. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers[J]. PLoS One, 2013, 8(4): e59364.
[2] Jing W, Prenner E J, Vogel H J, et al. Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin‐1[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 2005, 11(11): 735-743.
[3] Sakane F, Mizuno S, Takahashi D, et al. Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways[J]. Advances in biological regulation, 2018, 67: 101-108.
[4] Mizuno S, Sasai H, Kume A, et al. Dioleoyl‐phosphatidic acid selectively binds to α‐synuclein and strongly induces its aggregation[J]. FEBS letters, 2017, 591(5): 784-791.

1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)(16:0/16:0-PA)是一种磷脂,含有插入到sn-1和sn-2位置的长链(16:0)棕榈酸,能够用于制备脂质体、胶束和人工膜[1, 2]。在视黄酸和血清饥饿诱导的神经元分化过程中,小鼠神经母细胞瘤Neuro-2a细胞中的二酰甘油激酶z(DGKz)能够特异性产生1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]。1,2-Dipalmitoyl-sn-glycero-3-phosphate能够与α-突触核蛋白(α-syn)结合[4]

化学性质

Cas No. 169051-60-9 SDF
别名 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA
Canonical SMILES CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP([O-])(O)=O)=O.[Na+]
分子式 C35H68O8P•Na 分子量 670.9
溶解度 Chloroform: 1.6 mg/ml 储存条件 Store at 2-8°C, protect from light
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1 mM 1.4905 mL 7.4527 mL 14.9054 mL
5 mM 0.2981 mL 1.4905 mL 2.9811 mL
10 mM 0.1491 mL 0.7453 mL 1.4905 mL
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