1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)
(Synonyms: 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA) 目录号 : GC41825
1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)(16:0/16:0-PA)是一种磷脂,含有插入到sn-1和sn-2位置的长链(16:0)棕榈酸,能够用于制备脂质体、胶束和人工膜。
Cas No.:169051-60-9
Sample solution is provided at 25 µL, 10mM.
1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (16:0/16:0-PA) is a phospholipid containing long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions, which can be used to prepare liposomes, micelles and artificial membranes[1, 2]. During retinoic acid and serum starvation-induced neuronal differentiation, diacylglycerol kinase z (DGKz) in mouse neuroblastoma Neuro-2a cells can specifically produce 1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]. 1,2-Dipalmitoyl-sn-glycero-3-phosphate can bind to α-synuclein (α-syn)[4].
References:
[1] Sierra-Valdez F J, Forero-Quintero L S, Zapata-Morin P A, et al. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers[J]. PLoS One, 2013, 8(4): e59364.
[2] Jing W, Prenner E J, Vogel H J, et al. Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin‐1[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 2005, 11(11): 735-743.
[3] Sakane F, Mizuno S, Takahashi D, et al. Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways[J]. Advances in biological regulation, 2018, 67: 101-108.
[4] Mizuno S, Sasai H, Kume A, et al. Dioleoyl‐phosphatidic acid selectively binds to α‐synuclein and strongly induces its aggregation[J]. FEBS letters, 2017, 591(5): 784-791.
1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)(16:0/16:0-PA)是一种磷脂,含有插入到sn-1和sn-2位置的长链(16:0)棕榈酸,能够用于制备脂质体、胶束和人工膜[1, 2]。在视黄酸和血清饥饿诱导的神经元分化过程中,小鼠神经母细胞瘤Neuro-2a细胞中的二酰甘油激酶z(DGKz)能够特异性产生1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]。1,2-Dipalmitoyl-sn-glycero-3-phosphate能够与α-突触核蛋白(α-syn)结合[4]。
Cas No. | 169051-60-9 | SDF | |
别名 | 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA | ||
Canonical SMILES | CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP([O-])(O)=O)=O.[Na+] | ||
分子式 | C35H68O8P•Na | 分子量 | 670.9 |
溶解度 | Chloroform: 1.6 mg/ml | 储存条件 | Store at 2-8°C, protect from light |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.4905 mL | 7.4527 mL | 14.9054 mL |
5 mM | 0.2981 mL | 1.4905 mL | 2.9811 mL |
10 mM | 0.1491 mL | 0.7453 mL | 1.4905 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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