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1,4-Dicaffeoylquinic acid Sale

(Synonyms: 1,4-二咖啡酰奎宁酸; 1,4-DCQA) 目录号 : GC60434

1,4-Dicaffeoylquinic acid (1,4-DCQA) 是一种来自苍耳子 的苯丙素,可抑制 LPS 刺激的 TNF-α 产生。

1,4-Dicaffeoylquinic acid Chemical Structure

Cas No.:1182-34-9

规格 价格 库存 购买数量
1mg
¥1,170.00
现货
5mg
¥2,880.00
现货
10mg
¥4,500.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

1,4-Dicaffeoylquinic acid is a polyphenol that has been found in C. coronarium and has diverse biological activities.1,2,3,4 It scavenges DPPH radicals and inhibits xanthine oxidase (XO; IC50 = 7.36 ?M).1,2 1,4-Dicaffeoylquinic acid (25 ?M) decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16/F1 murine melanocytes, inhibits melanogenesis in the same cells, and decreases tyrosinase activity in B16/F1 cell lysates.3 It increases biliary flow in rats in a dose-dependent manner.4

1.Alberati, D., Moreau, J.-L., Lengyel, J., et al.Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophreniaNeuropharmacology62(2)1152-1161(2012) 2.Cao, W., Fang, Y., Wu, T., et al.Insights from multispectral and molecular docking investigation on the xanthine oxidase inhibition by 1,4-dicaffeoylquinic acidJ. Mol. Struct.1219128475(2020) 3.Ha, J.H., and Park, S.N.Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studiesBioorg. Med. Chem.26(14)4201-4208(2018) 4.Preziosi, P., Loscalzo, B., and Marmo, E.Comparison of choleretic effects of CYN and Na-dehydrocholateExperientia15(4)135-138(1959)

化学性质

Cas No. 1182-34-9 SDF
别名 1,4-二咖啡酰奎宁酸; 1,4-DCQA
Canonical SMILES OC1=CC=C(/C=C/C(O[C@H]2[C@H](O)C[C@@](C(O)=O)(OC(/C=C/C3=CC(O)=C(O)C=C3)=O)C[C@H]2O)=O)C=C1O
分子式 C25H24O12 分子量 516.45
溶解度 DMSO : 100 mg/mL (193.63 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.9363 mL 9.6815 mL 19.363 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL
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