1,4-Dicaffeoylquinic acid
(Synonyms: 1,4-二咖啡酰奎宁酸; 1,4-DCQA) 目录号 : GC60434
1,4-Dicaffeoylquinic acid (1,4-DCQA) 是一种来自苍耳子 的苯丙素,可抑制 LPS 刺激的 TNF-α 产生。
Cas No.:1182-34-9
Sample solution is provided at 25 µL, 10mM.
1,4-Dicaffeoylquinic acid is a polyphenol that has been found in C. coronarium and has diverse biological activities.1,2,3,4 It scavenges DPPH radicals and inhibits xanthine oxidase (XO; IC50 = 7.36 ?M).1,2 1,4-Dicaffeoylquinic acid (25 ?M) decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16/F1 murine melanocytes, inhibits melanogenesis in the same cells, and decreases tyrosinase activity in B16/F1 cell lysates.3 It increases biliary flow in rats in a dose-dependent manner.4
1.Alberati, D., Moreau, J.-L., Lengyel, J., et al.Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophreniaNeuropharmacology62(2)1152-1161(2012) 2.Cao, W., Fang, Y., Wu, T., et al.Insights from multispectral and molecular docking investigation on the xanthine oxidase inhibition by 1,4-dicaffeoylquinic acidJ. Mol. Struct.1219128475(2020) 3.Ha, J.H., and Park, S.N.Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studiesBioorg. Med. Chem.26(14)4201-4208(2018) 4.Preziosi, P., Loscalzo, B., and Marmo, E.Comparison of choleretic effects of CYN and Na-dehydrocholateExperientia15(4)135-138(1959)
Cas No. | 1182-34-9 | SDF | |
别名 | 1,4-二咖啡酰奎宁酸; 1,4-DCQA | ||
Canonical SMILES | OC1=CC=C(/C=C/C(O[C@H]2[C@H](O)C[C@@](C(O)=O)(OC(/C=C/C3=CC(O)=C(O)C=C3)=O)C[C@H]2O)=O)C=C1O | ||
分子式 | C25H24O12 | 分子量 | 516.45 |
溶解度 | DMSO : 100 mg/mL (193.63 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.9363 mL | 9.6815 mL | 19.363 mL |
5 mM | 0.3873 mL | 1.9363 mL | 3.8726 mL |
10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet