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1,4-DPCA

(Synonyms: 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid) 目录号 : GC12845

An inhibitor of prolyl 4-hydroxylase

1,4-DPCA Chemical Structure

Cas No.:331830-20-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥594.00
现货
5mg
¥540.00
现货
10mg
¥855.00
现货
25mg
¥1,710.00
现货
50mg
¥2,700.00
现货
100mg
¥4,410.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase with IC50 value of 3.6 μM [1].

Prolyl hydroxylase catalyzes the formation of hydroxyproline, which has a significant impact on the stability of collagen- the major connective tissue of the human body. Increased collagen deposition produces physical and biochemical signals to sustain tumor growth, resulting in tumor invasion and development. Therefore, 1,4-DPCA has been considered as a treatment strategy to suppress cancer progression as it inhibits collagen synthesis and deposition.

The suppression effect of 1,4-DPCA had been shown in human breast cancer cells. The activity of prolyl-4-hydroxylase was inhibited by 1, 4-DPCA, resulting in decreased deposition of collagen I and IV. In breast tumor cell lines ZR-75-1, T4-2, MDA-MB-157 and MDA-MB-231, treatment with 1,4-DPCA reduced cell proliferation and colony sizes, and formed smaller and less aggressive structures of these four cell lines[2].

References:
[1].  T. J. Franklin, W. P. Morris, P. N. Edwards, et al. Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. Biochemistry Journal 353, 333-338 (2001).
[2].  Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer, 2014 Jan 2; 14:1.

Chemical Properties

Cas No. 331830-20-7 SDF
别名 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid
化学名 4,4α-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid
Canonical SMILES O=C1C2=C(C3=NC=CC=C3C=C2)N([H])C=C1C(O)=O
分子式 C13H8N2O3 分子量 240.2
溶解度 ≤3mg/ml in DMSO;3mg/ml in dimethyl formamide 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.1632 mL 20.816 mL 41.632 mL
5 mM 0.8326 mL 4.1632 mL 8.3264 mL
10 mM 0.4163 mL 2.0816 mL 4.1632 mL
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