1-Heptadecanol
(Synonyms: 1-十七烷醇) 目录号 : GC61642
1-Heptadecanol 是一种长链伯醇，具有抗菌活性，来自Solena amplexicaulis叶子
Cas No.:1454-85-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves[1].
[1]. Soumendranath Chatterjee, et al. Antibacterial Activity of Long-Chain Primary Alcohols from Solena amplexicaulis Leaves. Proceedings of the Zoological Society volume 71, pages313-319(2018).
| Cas No. | 1454-85-9 | SDF | |
| 别名 | 1-十七烷醇 | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCO | ||
| 分子式 | C17H36O | 分子量 | 256.47 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.8991 mL | 19.4955 mL | 38.9909 mL |
| 5 mM | 0.7798 mL | 3.8991 mL | 7.7982 mL |
| 10 mM | 0.3899 mL | 1.9495 mL | 3.8991 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effects of high-intensity interval training on adipose tissue lipolysis, inflammation, and metabolomics in aged rats
Pflugers Arch 2020 Feb;472(2):245-258.PMID:32006095DOI:10.1007/s00424-020-02351-y.
High-intensity interval training (HIIT) is a time-efficient alternative to moderate-intensity continuous training (MICT) to improve metabolic health in older individuals. However, differences in adipose tissue metabolism between these two approaches are unclear. Here, we evaluated the effects of HIIT and MICT on metabolic phenotypes in aged rats. HIIT significantly decreased fat mass, increased percent lean mass, decreased fat-to-lean ratio, reduced serum high-sensitivity C-reactive protein, increased serum interleukin-10 levels, and decreased perirenal adipose tissue leptin compared with rats in the sedentary (SED) group. HIIT also increased pregnenolone, cortisol, and corticosterone in both adipose tissue and serum. Both exercise modalities enhanced hormone-sensitive lipase and adipose triglyceride lipase expression compared with the SED group and decreased palmitic acid, stearic acid, octadecadienoic acid, urea, 1-Heptadecanol, and α-tocopherol. MICT was related to glycerolipid metabolism, whereas HIIT was related to steroid hormone biosynthesis. Overall, HIIT showed more favorable regulation of anti-inflammatory activity than MICT.
Mechanism of the Immunomodulatory Effect of the Combination of Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus on Immunocompromised Rats
Front Immunol 2021 Jun 15;12:694344.PMID:34211480DOI:10.3389/fimmu.2021.694344.
Immunodeficiency is a very common condition in suboptimal health status and during the development or treatment of many diseases. Recently, probiotics have become an important means for immune regulation. The present study aimed to investigate the mechanism of the immunomodulatory effect of a combination of live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus (CBLEB), which is a drug used by approximately 10 million patients every year, on cyclophosphamide-immunosuppressed rats. Cyclophosphamide (40 mg/kg) was intraperitoneally injected to induce immunosuppression in a rat model on days 1, 2, 3, and 10. Starting from day 4, the rats were continuously gavaged with CBLEB solution for 15 days. The samples were collected to determine routine blood test parameters, liver and kidney functions, serum cytokine levels, gut microbiota, fecal and serum metabolomes, transcriptomes, and histopathological features. The results indicated that CBLEB treatment reduced cyclophosphamide-induced death, weight loss, and damage to the gut, liver, spleen, and lungs and eliminated a cyclophosphamide-induced increase in the mean hemoglobin content and GGT, M-CSF, and MIP-3α levels and a decrease in the red blood cell distribution width and total protein and creatinine levels in the blood. Additionally, CBLEB corrected cyclophosphamide-induced dysbiosis of the gut microbiota and eliminated all cyclophosphamide-induced alterations at the phylum level in rat feces, including the enrichment in Proteobacteria, Fusobacteriota, and Actinobacteriota and depletion of Spirochaetota and Cyanobacteria. Furthermore, CBLEB treatment alleviated cyclophosphamide-induced alterations in the whole fecal metabolome profile, including enrichment in 1-Heptadecanol, succinic acid, hexadecane-1,2-diol, nonadecanoic acid, and pentadecanoic acid and depletion of benzenepropanoic acid and hexane. CBLEB treatment also alleviated cyclophosphamide-induced enrichment in serum D-lyxose and depletion of serum succinic acid, D-galactose, L-5-oxoproline, L-alanine, and malic acid. The results of transcriptome analysis indicated that the mechanism of the effect of CBLEB was related to the induction of recovery of cyclophosphamide-altered carbohydrate metabolism and signal transduction. In conclusion, the present study provides an experimental basis and comprehensive analysis of application of CBLEB for the treatment of immunodeficiency.
Antifeedant activity of long-chain alcohols, and fungal and plant metabolites against pea aphid ( Acyrthosiphon pisum) as potential biocontrol strategy
Nat Prod Res 2019 Sep;33(17):2471-2479.PMID:29595339DOI:10.1080/14786419.2018.1452013.
Aphids are noxious insect pests of major crops including cereals and legumes. Particularly, pea aphid (Acyrthosiphon pisum) causes significant yield and quality loses in pea. Crop protection is largely based on noxious chemical pesticides which have prompted a renewed interest in the discovery of natural products as alternatives to synthetic insecticides. In this study different classes of natural compounds were tested in dual choice bioassays to evaluate their feeding deterrence and mortality effect on pea aphid. High feeding deterrence was produced by some of the compounds, particularly1-hexadecanol, gliotoxin, cyclopaldic acid and seiridin. On the contrary, aphid mortality was low although significant for 1-Heptadecanol, cytochalasin A, 1-nonadecanol and gliotoxin. Phytotoxicity assessment showed low or imperceptible plant damaged for cytochalasin A, seiridin and 1-nonadecanol. The results obtained showed the potential of seiridin to be used as an alternative to synthetic insecticides.
Difference in Surface Properties between Insoluble Monolayer and Adsorbed Film from Kinetics of Water Evaporation and BAM Image
J Phys Chem B 2004 May 20;108(20):6351-8.PMID:18950121DOI:10.1021/jp0306287.
The evaporation rate of water molecules across three kinds of interfaces (air/water interface (1), air/surfactant solution interface (2), and air/water interface covered by insoluble monolayer (3)) was examined using a remodeled thermogravimetric balance. There was no difference in both the evaporation rate and the activation energy for the first two interfaces for three types of surfactant solutions below and above the critical micelle concentration (cmc). This means that the molecular surface area from the Gibbs surface excess has nothing to do with the evaporation rate. In the third case, the insoluble monolayer of 1-Heptadecanol decreased the evaporation rate and increased the activation energy, indicating a clear difference between an insoluble monolayer and an adsorbed film of soluble surfactant. This difference was substantiated by BAM images, too. The images of three surfactant solution interfaces were similar to that of just the water surface, while distinct structures of molecular assemblies were observed for the insoluble monolayer. The concentration profile of water molecules in an air/liquid interfacial region was derived by Fix's second law. The profile indicates that a definite layer just beneath the air/liquid interface of the surfactant solution is made mostly of water molecules and that the layer thickness is a few times the root-mean-square displacement %@mt;sys@%%@rl;;@%2%@ital@%Dt%@rsf@%%@rlx@%%@mx@% of the water molecules. The thickness was found to be more than a few nanometers, as estimated from several relaxation times derived from the other kinetics than evaporation of amphiphilic molecules in aqueous systems and a maximum evaporation rate of purified water.
Fruit Volatiles of Creeping Cucumber (Solena amplexicaulis) Attract a Generalist Insect Herbivore
J Chem Ecol 2020 Mar;46(3):275-287.PMID:31989491DOI:10.1007/s10886-020-01154-w.
Herbivorous insects employ host plant volatile blends as cue for host recognition. Adults of Aulacophora foveicollis Lucas (Coleoptera: Chrysomelidae) feed on leaves, flowers, and fruits of Solena amplexicaulis (Lam.) Gandhi (syn: Melothria heterophylla) (Cucurbitaceae), commonly known as creeping cucumber. Currently, this pest is controlled by insecticides application. Hence, it is necessary to find out volatile components from fruits attracting the insect, which might be used for eco-friendly pest management program. behavioral responses of females were measured by Y-tube olfactometer bioassays towards volatile blends from undamaged (UD), insect-damaged (ID), and mechanically damaged (MD) fruits with the aim to identify the compounds responsible for host fruit location. Volatile organic compounds were identified and quantified by GC-MS and GC-FID analyses, respectively. Nonanal was predominant in volatile blends of UD, ID, and MD fruits. 1-Octen-3-ol, 3-octanone, 2-octanol, heptadienal (2E,4E), 1-pentadecanol, and 1-hexadecanol were present in volatile blends of ID and MD fruits, but females did not show response to these six compounds. 1-Octanol and 1-Heptadecanol were unique in volatile blends of UD fruits after 4 hr of damage, but females did not show response to these compounds. Females were more attracted to volatile blends from UD fruits after 4 hr of damage in comparison to volatile blends released by UD fruits, due to increased emissions of (E,Z)-2,6-nonadienal and 2E-nonenal. A synthetic blend of 3.35 μg (E,Z)-2,6-nonadienal and 1.72 μg 2E-nonenal dissolved in 25 μl CH2Cl2 could be used for the development of baited traps to control this insect pest in integrated pest management strategies.