1-Methyladenosine

1-Methyladenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases.^1,2,3 The urinary excretion of 1-methyladenosine is elevated in several forms of cancer, supporting its use as a biomarker in early detection.^4,5,6 It can also be monitored in serum.⁷ Urinary levels of 1-methyladenosine also increase during active rheumatoid arthritis.⁸

1.Munns, T.W., and Sims, H.F.Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cellsJ. Biol. Chem.250(6)2143-2149(1975) 2.Vold, B.Modified nucleosides of Bacillus subtilis transfer ribonucleic acidsJ. Bacteriol.127(1)258-267(1976) 3.Chujo, T., and Suzuki, T.Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAsRNA18(12)2269-2276(2012) 4.Reynaud, C., Bruno, C., Boullanger, P., et al.Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodiesCancer Lett.255-262(1991) 5.Seidel, A., Brunner, S., Seidel, P., et al.Modified nucleosides: An accurate tumour marker for clinical diagnosis of cancer, early detection and therapy controlBr. J. Cancer.94(11)1726-1733(2006) 6.Hsu, W.Y., Chen, C.J., Huang, Y.C., et al.Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in TaiwanesePLoS One8(12)1-8(2013) 7.Chen, F., Xue, J., Zhou, L., et al.Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic methodAnal. Bioanal. Chem.401(6)1899-1904(2011) 8.Tebib, J.G., Reynaud, C., Cedoz, J.P., et al.Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis processBr. J. Rheumatol.36(9)990-995(1997)