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1-Methylnicotinamide (chloride) Sale

(Synonyms: 3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride) 目录号 : GC42000

A metabolite of nicotinamide

1-Methylnicotinamide (chloride) Chemical Structure

Cas No.:1005-24-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥539.00
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100mg
¥210.00
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500mg
¥490.00
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Sample solution is provided at 25 µL, 10mM.

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase . It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

化学性质

Cas No. 1005-24-9 SDF
别名 3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride
Canonical SMILES NC(C1=CC=C[N+](C)=C1)=O.[Cl-]
分子式 C7H9N2O•Cl 分子量 172.6
溶解度 10mg/ml in PBS (pH 7.2) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.7937 mL 28.9687 mL 57.9374 mL
5 mM 1.1587 mL 5.7937 mL 11.5875 mL
10 mM 0.5794 mL 2.8969 mL 5.7937 mL
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