1-Methyluric acid
(Synonyms: 1-甲基尿酸) 目录号 : GC31610
1-甲基尿酸是人体三种主要的茶碱代谢物之一。1-甲基尿酸是尿路结石中的嘌呤成分之一。甲基化嘌呤来源于甲基黄嘌呤（咖啡因、茶碱和可可碱）的代谢。作用于膀胱黏膜，并能增加血糖，胰岛素，甘油三酯和胆固醇的水平。
Cas No.:708-79-2
Sample solution is provided at 25 µL, 10mM.
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1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.
Perfusion of the urinary bladder with 1-Methyl uric acid solution shows an increase in the serum total cholesterol level, true triglyceride level, glucose level and insulin level on comparison with perfusion of the urinary bladder with distilled water[1].
[1]. Balasubramanian T, et al. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003 Oct 5;3:930-6.
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Animal experiment: |
Rats[1]Adult albino rats of Wistar strain of either sex weighing 200-300 g rats are used for the present study. Thirty albino rats are divided into three groups of ten each. Group I serves as the control group perfused with distilled water. Following cannulation, the bladder is perfused with distilled water. Group II serves as the uric acid perfused group. Group III serves as the 1-Methyl uric acid perfused group. The animals of this group are treated in a similar way as those of control group (Group I) except that the bladder is perfused with the aqueous solution of 1-Methyl uric acid (0.0024 g/100 mL) instead of distilled water[1]. |
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References: [1]. Balasubramanian T, et al. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003 Oct 5;3:930-6. |
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| Cas No. | 708-79-2 | SDF | |
| 别名 | 1-甲基尿酸 | ||
| Canonical SMILES | O=C(NC(N1)=C2NC1=O)N(C)C2=O | ||
| 分子式 | C6H6N4O3 | 分子量 | 182.14 |
| 溶解度 | H2O : < 0.1 mg/mL (insoluble); DMSO : < 1 mg/mL (insoluble or slightly soluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.4903 mL | 27.4514 mL | 54.9028 mL |
| 5 mM | 1.0981 mL | 5.4903 mL | 10.9806 mL |
| 10 mM | 0.549 mL | 2.7451 mL | 5.4903 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet