1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC
(Synonyms: 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphatidylcholine, Porphyrin-lipid, Pyro-PtdCho) 目录号 : GC90829一种磷脂-卟啉共轭物
Cas No.:1287795-07-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porprin conjugate that is composed of phosphatidylcholine containing palmitic acid at the sn-1 position and the photosensitizer pyropheophorbide a at the sn-2 position.1 Lipid nanoparticles (LNPs) containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA are dissociated under irradiation with near-infrared light (NIR) in PC3-Luc6 cells. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC then enters the endolysosomal membrane and generates reactive oxygen species (ROS), which disrupt the membrane and allow the release of FAM-labeled siRNA into the cytosol. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with the mitotic inhibitor paclitaxel , combined with laser irradiation, reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model.2
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.9878 mL | 4.9392 mL | 9.8785 mL |
| 5 mM | 0.1976 mL | 0.9878 mL | 1.9757 mL |
| 10 mM | 0.0988 mL | 0.4939 mL | 0.9878 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。