1-Palmitoyl-d9-2-Palmitoyl-sn-glycero-3-PE

1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PE is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PE by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) is a naturally occurring PE containing C16:0 fatty acids at the sn-1 and sn-2 positions. It belongs to a class of phospholipids that are the most abundant lipids in the inner leaflet of the plasma membrane.1 1,2-DPPE interacts with cholesterol to form a condensed lipid monolayer with tight hydrogen bonding of the 1,2-DPPE interheadgroups, resulting in a more fluid membrane that may aid in transport and signaling across the bilayer.2,3

|1. Vance, J.E., and Tasseva, G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim. Biophys. Acta 1831(3), 543-554 (2013).|2. Leekumjorn, S., and Sum, A.K. Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayers. Biophys. J. 90(11), 3951-3965 (2006).|3. McQuaw, C.M., Sostarecz, A.G., Zheng, L., et al. Lateral heterogeneity of dipalmitoylphosphatidylethanolamine-cholesterol Langmuir-Blodgett films investigated with imaging time-of-flight secondary ion mass spectrometry and atomic force microscopy. Langmuir 21(3), 807-813 (2005).