1-Pentadecanol
(Synonyms: 1-十五醇) 目录号 : GC61645
1-Pentadecanol 用作茉莉花不对称合成的起始试剂，充当脂肪醇。具有抗粉刺活性
Cas No.:629-76-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Pentadecanol is a naturally occurring antiacne agent[1].
[1]. I Kubo, et al. Naturally occurring antiacne agents. J Nat Prod. 1994 Jan;57(1):9-17.
| Cas No. | 629-76-5 | SDF | |
| 别名 | 1-十五醇 | ||
| Canonical SMILES | CCCCCCCCCCCCCCCO | ||
| 分子式 | C15H32O | 分子量 | 228.41 |
| 溶解度 | DMSO : 33.33 mg/mL (145.92 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3781 mL | 21.8905 mL | 43.7809 mL |
| 5 mM | 0.8756 mL | 4.3781 mL | 8.7562 mL |
| 10 mM | 0.4378 mL | 2.189 mL | 4.3781 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Novel antagonists of alcohol inhibition of l1-mediated cell adhesion: multiple mechanisms of action
Mol Pharmacol 2002 Nov;62(5):1053-60.PMID:12391267DOI:10.1124/mol.62.5.1053.
1-Octanol antagonizes ethanol inhibition of L1-mediated cell adhesion and prevents ethanol teratogenesis in mouse whole embryo culture. Herein, we identify a new series of alcohol antagonists and study their mechanism of action. Cell aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of 100 mM ethanol or 2 mM 1-butanol and candidate antagonists. Antagonist potency for 1-alcohols increased progressively over 5 log orders from 1-pentanol (C5) to 1-dodecanol (C12). Antagonist potency declined from 1-dodecanol (C12) to 1-tridecanol (C13), and 1-tetradecanol (C14) and 1-Pentadecanol (C15) were inactive. The presence and position of a double bond in the 1-butanol molecule determined whether a compound was a full agonist (1-butanol), a mixed agonist-antagonist (2-buten-1-ol), or an antagonist (3-buten-1-ol). Increasing the concentration of agonist (1-butanol or ethanol) overcame the antagonism of 3-buten-1-ol, benzyl alcohol, cyclopentanol, and 3-pentanol, but not that of 4-methyl-1-pentanol, 2-methyl-2-pentanol, 1-pentanol, 2-pentanol, 1-octanol, and 2,6-di-isopropylphenol (propofol), suggesting that the mechanisms of antagonism may differ between these groups of compounds. These findings suggest that selective straight, branched, and cyclic alcohols may act at multiple, discrete sites to antagonize the actions of ethanol and 1-butanol on L1-mediated cell-cell adhesion.
Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix
J Med Food 2017 Aug;20(8):797-803.PMID:28731365DOI:10.1089/jmf.2016.3898.
The aim of this study was to explore the chemical composition and the effect of essential oil of Angelicae dahuricae radix on a nitroglycerin (NTG)-induced rat model of migraine. The CO2 supercritical fluid extraction method was optimized for the extraction of essential oil of A. dahuricae radix (EOAD) and its chemical composition was determined. The migraine model was established by subcutaneous injection of NTG (10 mg/kg) 1 h after the last administration of EOAD. The therapeutic effect of EOAD and its underlying mechanism were assessed by monitoring behavioral changes, levels of nitric oxide (NO) in serum and brain tissues, plasma levels of calcitonin gene-related peptide (CGRP) and endothelin (ET), and ET/NO ratio. The optimal conditions for CO2 supercritical fluid extraction of EOAD, as determined by orthogonal test [L9(34)], were as follows: 2 h extraction time, 20 MPa pressure, 40°C temperature, and 30 mesh. The yield of EOAD was 1.8%. On gas chromatography-mass spectrometry, 45 peaks were found in EOAD, and 22 compounds were identified and quantified. The main constituents of EOAD were 1-dodecanol (13.71%), elemene (7.54%), palmitic acid ethyl ester (7.32%), α-pinene (6.25%), and 1-Pentadecanol (6.08%). Compared with rat migraine model controls, EOAD (35, 70, and 140 mg/kg) significantly reduced the number of head shaking, head scratching, and hind leg shooting events, decreased serum and brain NO levels, decreased plasma CGRP, and increased ET levels in rats. ET/NO ratio was elevated to 28.68 in the EOAD high-dose group. EOAD ameliorates NTG-induced migraine in rats likely by modulating the levels of vasoactive substances.
Fruit Volatiles of Creeping Cucumber (Solena amplexicaulis) Attract a Generalist Insect Herbivore
J Chem Ecol 2020 Mar;46(3):275-287.PMID:31989491DOI:10.1007/s10886-020-01154-w.
Herbivorous insects employ host plant volatile blends as cue for host recognition. Adults of Aulacophora foveicollis Lucas (Coleoptera: Chrysomelidae) feed on leaves, flowers, and fruits of Solena amplexicaulis (Lam.) Gandhi (syn: Melothria heterophylla) (Cucurbitaceae), commonly known as creeping cucumber. Currently, this pest is controlled by insecticides application. Hence, it is necessary to find out volatile components from fruits attracting the insect, which might be used for eco-friendly pest management program. behavioral responses of females were measured by Y-tube olfactometer bioassays towards volatile blends from undamaged (UD), insect-damaged (ID), and mechanically damaged (MD) fruits with the aim to identify the compounds responsible for host fruit location. Volatile organic compounds were identified and quantified by GC-MS and GC-FID analyses, respectively. Nonanal was predominant in volatile blends of UD, ID, and MD fruits. 1-Octen-3-ol, 3-octanone, 2-octanol, heptadienal (2E,4E), 1-Pentadecanol, and 1-hexadecanol were present in volatile blends of ID and MD fruits, but females did not show response to these six compounds. 1-Octanol and 1-heptadecanol were unique in volatile blends of UD fruits after 4 hr of damage, but females did not show response to these compounds. Females were more attracted to volatile blends from UD fruits after 4 hr of damage in comparison to volatile blends released by UD fruits, due to increased emissions of (E,Z)-2,6-nonadienal and 2E-nonenal. A synthetic blend of 3.35 μg (E,Z)-2,6-nonadienal and 1.72 μg 2E-nonenal dissolved in 25 μl CH2Cl2 could be used for the development of baited traps to control this insect pest in integrated pest management strategies.
The effect of various drying techniques on apricot volatiles analysed using direct thermal desorption-GC-TOF/MS
Talanta 2007 Sep 15;73(2):321-5.PMID:19073034DOI:10.1016/j.talanta.2007.03.048.
The volatile constituents obtained from dried Sekerpare-type apricots by direct thermal desorption were examined using gas chromatography (GC) coupled with time of flight mass spectrometry (TOF/MS). Various commercially used drying techniques (sun, hot air and microwaves) were employed to dry the apricot samples before desorption. Some apricots were dried using only a desiccator and the volatile desorbed from these was used as a standard. Limonene (16.33%); (E)-2-hexenal (9.32%); gamma-decalactone (7.89%); butyl acetate (6.94%); beta-ionone (5.96%); acetic acid (4.83%) and isobutanal were found to be the major components in the desiccator-dried samples. This is the first study to report the detection of isobutanal, tridecanol and 1-Pentadecanol as dried apricot constituents. The profiles of the volatiles desorbed changed when other drying techniques (sun, hot air, and microwaves) were used. The major components found in samples dried by these three methods were 5-hydroxymethylfurfural (5-HMF), 2,3-dihydro-4-H-pyran-4-one and furfural.
Drug "Pent-Up" in Hollow Magnetic Prussian Blue Nanoparticles for NIR-Induced Chemo-Photothermal Tumor Therapy with Trimodal Imaging
Adv Healthc Mater 2017 Jul;6(14).PMID:28464527DOI:10.1002/adhm.201700005.
The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-Pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo. Moreover, the system clearly indicates tumor site with trimodal imaging of magnetic resonance imaging, photoacoustic tomography imaging, and infrared thermal imaging. Furthermore, the system achieves efficient chemo-photothermal combined tumor therapy in vivo with 808 nm laser irradiation for 5 min at 1.2 W cm-2 , revealing the good tumor inhibition effect comparing with those of chemotherapy or photothermal therapy alone. The system is also confirmed to be biocompatible in regard to the mortality rate.