Home>>Signaling Pathways>> Proteases>> Endogenous Metabolite>>1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC

1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC

(Synonyms: L-α-磷脂酰胆碱-β-花生四烯酰-γ-硬脂酰,SAPC) 目录号 : GC11139

A phospholipid

1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC Chemical Structure

Cas No.:35418-59-8

规格 价格 库存 购买数量
5mg
¥1,126.00
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10mg
¥2,015.00
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25mg
¥4,029.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

1-Stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC) is a phospholipid containing stearic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and has been found in human stenotic aortic valves and atherosclerotic plaques.[1],[2] Levels of SAPC are increased in the subepithelial invasive region compared to the superficial region of tumor tissue samples from patients with superficial-type pharyngeal squamous cell carcinoma.[3] SAPC unilamellar vesicles have been used as substrates to quantify the activity of secretory phospholipase A2 (sPLA2) in the presence or absence of inhibitors.[4] SAPC has also been used in the formation of lipid bilayers to study the effects of lipid composition on bilayer phase transitions.[5]

Reference
[1]. Milne, G.L., Seal, J.R., Havrilla, C.M., et al. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J. Lipid Res. 46(2), 307-319 (2005).
[2]. Lehti, S., Käkelä, R., Hörkkö, S., et al. Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves. PLoS One 8(6), e65810 (2013).
[3]. Ishikawa, S., Tateya, I., Hayasaka, T., et al. The distribution of phosphatidylcholine species in superficial-type pharyngeal carcinoma. Biomed. Res. Int. 5387913, (2017).
[4]. Schebb, N.H., Falck, D., Faber, H., et al. Fast method for monitoring phospholipase A2 activity by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. A 1216(27), 5249-5255 (2009).
[5]. Tada, K., Goto, M., Tamai, N., et al. Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chain. Ann. N.Y. Acad. Sci. 1189(1), 77-85 (2010).

Chemical Properties

Cas No. 35418-59-8 SDF
别名 L-α-磷脂酰胆碱-β-花生四烯酰-γ-硬脂酰,SAPC
化学名 1-ocatadeconyl-2R-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glyceryl-3-phosphorylcholine
Canonical SMILES O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O
分子式 C46H84NO8P 分子量 810.1
溶解度 30 mg/ml in Ethanol 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 1.2344 mL 6.1721 mL 12.3442 mL
5 mM 0.2469 mL 1.2344 mL 2.4688 mL
10 mM 0.1234 mL 0.6172 mL 1.2344 mL
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