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11-deoxy-11-methylene Prostaglandin D2 Sale

(Synonyms: 11deoxy11methylene PGD2) 目录号 : GC40335

A stable, isosteric PGD2 analog

11-deoxy-11-methylene Prostaglandin D2 Chemical Structure

Cas No.:100648-29-1

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1mg
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5mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Prostaglandin D2 is one of the five primary enzymatic prostaglandins derived directly from PGH2 . PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay. The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.

Chemical Properties

Cas No. 100648-29-1 SDF
别名 11deoxy11methylene PGD2
Canonical SMILES CCCCCC(O)/C=C/[C@H]1C(=C)CC(O)C1C/C=C\CCCC(=O)O
分子式 C21H34O4 分子量 350.5
溶解度 DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 3.75 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.8531 mL 14.2653 mL 28.5307 mL
5 mM 0.5706 mL 2.8531 mL 5.7061 mL
10 mM 0.2853 mL 1.4265 mL 2.8531 mL
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