13,14-dihydro-15-keto Prostaglandin D2-d9
(Synonyms: 13,14-dihydro-15-keto-PGD2-d9) 目录号 : GC46424
A neuropeptide with diverse biological activities
Cas No.:2738376-77-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
13,14-dihydro-15-keto-Prostaglandin D2-d9 (13,14-dihydro-15-keto PGD2-d9) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-MS. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.1 It also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4
1.Rangachari, P.K., and Betti, P.A.Biological activity of metabolites of PGD2 on canine proximal colonAm. J. Physiol.264(5 Pt 1)G886-G894(1993) 2.Hirai, H., Tanaka, K., Yoshie, O., et al.Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2J. Exp. Med.193(2)255-261(2001) 3.Liston, T.E., and Roberts, L.J., IIMetabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteerJ. Biol. Chem.260(24)13172-13180(1985) 4.Morrow, J.D., Prakash, C., Awad, J.A., et al.Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assayAnal. Biochem.193(1)142-148(1991)
| Cas No. | 2738376-77-5 | SDF | |
| 别名 | 13,14-dihydro-15-keto-PGD2-d9 | ||
| Canonical SMILES | O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)C1=O | ||
| 分子式 | C20H23D9O5 | 分子量 | 361.5 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7663 mL | 13.8313 mL | 27.6625 mL |
| 5 mM | 0.5533 mL | 2.7663 mL | 5.5325 mL |
| 10 mM | 0.2766 mL | 1.3831 mL | 2.7663 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。