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13C17-Mycophenolic Acid Sale

(Synonyms: 霉酚酸-(全碳-13)) 目录号 : GC49759

An internal standard for the quantification of mycophenolic acid

13C17-Mycophenolic Acid Chemical Structure

Cas No.:1202866-92-9

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1.2 ml
¥16,719.00
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Sample solution is provided at 25 µL, 10mM.

Description

13C17-Mycophenolic acid is intended for use as an internal standard for the quantification of mycophenolic acid by GC- or LC-MS. Mycophenolic acid is an immunosuppressive microbial metabolite that has been found in P. brevicompactum.1,2 It is also an active metabolite of mycophenolate mofetil that is formed via carboxylesterase 1 (CES1) and CES2.3 Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays) and inhibits DNA synthesis in L strain mouse fibroblasts when used at concentrations ranging from 0.1 to 10 µg/ml.4,5 It is active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/ml), as well as various strains of S. aureus (MICs = 31.25-125 µg/ml).2 Mycophenolic acid (150 mg/kg) reduces splenomegaly in a mouse model of Friend virus-induced leukemia.6 It decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep red blood cells (RBCs) when administered at doses ranging from 60 to 240 mg/kg.1 Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant rejection.

1.Mitsui, A., and Suzuki, S.Immunosuppressive effect of mycophenolic acidJ. Antibiot. (Tokyo)22(8)358-363(1969) 2.Noto, T., Sawada, M., Ando, K., et al.Some biological properties of mycophenolic acidJ. Antibiot. (Tokyo)22(4)165-169(1969) 3.Fujiyama, N., Miura, M., Kato, S., et al.Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetilDrug Metab. Dispos.38(12)2210-2217(2010) 4.Watkins, W.J., Chen, J.M., Cho, A., et al.Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDHBioorg. Med. Chem. Lett.16(13)3479-3483(2006) 5.Franklin, T.J., and Cook, J.M.The inhibition of nucleic acid synthesis by mycophenolic acidBiochem J.113(3)515-524(1969) 6.Williams, R.H., Lively, D.H., DeLong, D.C., et al.Mycophenolic acid: Antiviral and antitumor propertiesJ. Antibiot. (Tokyo)21(7)463-464(1968)

化学性质

Cas No. 1202866-92-9 SDF Download SDF
别名 霉酚酸-(全碳-13)
Canonical SMILES O=[13C]1O[13CH2][13C]2=[13C]1[13C](O)=[13C]([13CH2][13CH]=[13C]([13CH2][13CH2][13C](O)=O)[13CH3])[13C](O[13CH3])=[13C]2[13CH3]
分子式 [13C]17H20O6 分子量 337.2
溶解度 Acetonitrile: soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 2.9656 mL 14.828 mL 29.656 mL
5 mM 0.5931 mL 2.9656 mL 5.9312 mL
10 mM 0.2966 mL 1.4828 mL 2.9656 mL
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