14(S)-HDHA-d5
(Synonyms: 14(S)-HDoHE-d5,14(S)-hydroxy Docosahexaenoic Acid-d5,FA 22:6-d5) 目录号 : GC9174314(S)-HDHA-d5 is intended for use as an internal standard for the quantification of 14(S)-HDHA by GC- or LC-MS.
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
14(S)-HDHA-d5 is intended for use as an internal standard for the quantification of 14(S)-HDHA by GC- or LC-MS. 14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA;).1 It is a precursor to the pro-resolving mediator maresin 1 and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis.
References:
[1].Serhan, C.N., Yang, R., Martinod, K., et al.Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actionsJ. Exp. Med.206(1)15-23(2009).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8612 mL | 14.3062 mL | 28.6123 mL |
| 5 mM | 0.5722 mL | 2.8612 mL | 5.7225 mL |
| 10 mM | 0.2861 mL | 1.4306 mL | 2.8612 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。