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15-keto-17-phenyl trinor Prostaglandin F2α Sale

(Synonyms: 15keto17phenyl trinor PGF2α) 目录号 : GC41936

An analytical standard

15-keto-17-phenyl trinor Prostaglandin F2α Chemical Structure

Cas No.:949564-89-0

规格 价格 库存 购买数量
1mg
¥873.00
现货
5mg
¥3,941.00
现货
10mg
¥6,990.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye.

Chemical Properties

Cas No. 949564-89-0 SDF
别名 15keto17phenyl trinor PGF2α
Canonical SMILES O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/C(CCC2=CC=CC=C2)=O)[C@H](O)C1
分子式 C23H30O5 分子量 386.5
溶解度 DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2.5 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.5873 mL 12.9366 mL 25.8732 mL
5 mM 0.5175 mL 2.5873 mL 5.1746 mL
10 mM 0.2587 mL 1.2937 mL 2.5873 mL
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