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17α,20β-Dihydroxy-4-pregnen-3-one

(Synonyms: 4-孕烷-17Α,20Β-二醇-3-酮,17α,20β-DHP,17α,20β-dihydroxy Progesterone) 目录号 : GC41321

A maturation-inducing hormone

17α,20β-Dihydroxy-4-pregnen-3-one Chemical Structure

Cas No.:1662-06-2

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1mg
¥582.00
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5mg
¥1,747.00
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10mg
¥3,210.00
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Sample solution is provided at 25 µL, 10mM.

Description

17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 µg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production of 17α,20β-DHP either in vivo or in vitro.[2] 17α,20β-DHP has also been reported to influence spermiation by stimulating milt production when administered at 5 mg/kg to various male teleosts.[1]

Reference:
[1]. Milla, S., Terrien, X., Sturm, A., et al. Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: Implication with 17alpha, 2βdihydroxyprogesterone on the milt fluidity? Reproductive Biology and Endocrinology 6, 19 (2008).
[2]. Planas, J.V., and Swanson, P. Maturation-associated changes in the response of the salmon testis to the steroidogenic actions of gonadotropins (GTH I and GTH II) in vitro. Biology of Reproduction 52(3), 697-704 (1995).

化学性质

Cas No. 1662-06-2 SDF
别名 4-孕烷-17Α,20Β-二醇-3-酮,17α,20β-DHP,17α,20β-dihydroxy Progesterone
化学名 17,20R-dihydroxy-pregn-4-en-3-one
Canonical SMILES C[C@@H](O)[C@@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
分子式 C21H32O3 分子量 332.5
溶解度 1mg/mL in ethanol, 1mg/mL in methanol, 1mg/mL in acetonitrile 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 3.0075 mL 15.0376 mL 30.0752 mL
5 mM 0.6015 mL 3.0075 mL 6.015 mL
10 mM 0.3008 mL 1.5038 mL 3.0075 mL
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