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17-phenyl trinor Prostaglandin F2α ethyl amide-d4 Sale

(Synonyms: Bimatoprost-d4, 15(S)-Bimatoprost-d4, 17-phenyl trinor PGF2α ethyl amide-d4) 目录号 : GC46459

A neuropeptide with diverse biological activities

17-phenyl trinor Prostaglandin F2α ethyl amide-d4 Chemical Structure

规格 价格 库存 购买数量
25 μg
¥942.00
现货
50 μg
¥1,799.00
现货
100 μg
¥3,392.00
现货
1 mg
¥24,498.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

17-phenyl trinor Prostaglandin F ethyl amide (17-phenyl trinor PGF ethyl amide) is sold under the Allergan trade name Bimatoprost and is an F-series PG analog which has been approved for use as an ocular hypotensive drug.1 Investigations in our lab have shown that 17-phenyl trinor PGF ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.2 The free acid, 17-phenyl trinor PGF, is a potent FP receptor agonist.3,4 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

1.Woodward, D.F., Krauss, A.H.P., Chen, J., et al.The pharmacology of Bimatoprost (LumiganTM)Survey of Ophthalmology45S337-S345(2001) 2.Maxey, K.M., Johnson, J., Camras, C.B., et al.The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonistSuv. Ophthalmol.47(4)S34-S40(2002) 3.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 4.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994)

Chemical Properties

Cas No. N/A SDF
别名 Bimatoprost-d4, 15(S)-Bimatoprost-d4, 17-phenyl trinor PGF2α ethyl amide-d4
Canonical SMILES O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
分子式 C25H33D4NO4 分子量 419.6
溶解度 DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): .3 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3832 mL 11.9161 mL 23.8322 mL
5 mM 0.4766 mL 2.3832 mL 4.7664 mL
10 mM 0.2383 mL 1.1916 mL 2.3832 mL
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