(±)-Epinephrine-d3
(Synonyms: (±)-Adrenaline-d3,DL-Adrenaline-d3,DL-Epinephrine-d3) 目录号 : GC91496(±)-Epinephrine-d3 is intended for use as an internal standard for the quantification of (±)-epinephrine by GC- or LC-MS.
Cas No.:1189977-29-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(±)-Epinephrine-d3 is intended for use as an internal standard for the quantification of (±)-epinephrine by GC- or LC-MS. (±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).1,2,3 Through these receptors, (±)-epinephrine may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression.[3] Formulations containing (±)-epinephrine have been used in the emergency treatment of severe allergic reactions and the induction and maintenance of mydriasis during intraocular surgery.
References:
[1].Rothman, R.B., Vu, N., Partilla, J.S., et al.In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substratesJ. Pharmacol. Exp. Ther.307(1)138-145(2003).
[2].Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al.Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cellsN.-S. Arch. Pharmacol.369(2)151-159(2004).
[3].Ahles, A., and Englehardt, S.Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in diseasePharmacol. Rev.66(3)598-637(2014).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.3706 mL | 26.8528 mL | 53.7057 mL |
| 5 mM | 1.0741 mL | 5.3706 mL | 10.7411 mL |
| 10 mM | 0.5371 mL | 2.6853 mL | 5.3706 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。