(±)-Methadone-d3 (CRM)
(Synonyms: DL-Methadone-d3) 目录号 : GC91666(±)-Methadone-d3 (CRM) is intended for use as an internal standard for the quantification of methadone by GC- or LC-MS.
Cas No.:60263-63-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
(±)-Methadone-d3 (CRM) is intended for use as an internal standard for the quantification of methadone by GC- or LC-MS. (±)-Methadone is categorized as an opioid.[1] It has analgesic activity.[2] Formulations containing (±)-methadone have been used in the treatment of opioid addiction. (±)-Methadone-d3 is regulated as a Schedule II compound in the United States. (±)-Methadone-d3 (CRM) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
References:
[1].Raynor, K., Kong, H., Chen, Y., et al.Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptorsMol. Pharm.45(2)330-334(1994).
[2].He, L., Kim, J., Ou, C., et al.Methadone antinociception is dependent on peripheral opioid receptorsJ. Pain.10(4)369-379(2009).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2 mL | 16 mL | 32 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。