2'-Deoxyadenosine-5'-O-triphosphate (sodium salt hydrate)

2'-Deoxyadenosine-5'-O-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5’-triphosphate .¹ dATP is a substrate for DNA polymerase in the synthesis of DNA.² It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.¹ dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.^3,4 dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.⁵