2'-O-MOE-5-Me-C(Bz)
目录号 : GC66713
2'-O-MOE-5-Me-C (Bz) 是一种用于立体选择性合成核苷烷基膦酸酯的核苷酸。
Cas No.:163759-94-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates[1].
[1]. Vasulinga T. Ravikumar, et al. Stereoselective Synthesis of Alkylphosphonates: A Facile Rearrangement of Cyanoethyl-Protected Nucleoside Phosphoramidites. Org. Proc. Res. Dev. 2004, 8, 4, 603-608.
| Cas No. | 163759-94-2 | SDF | Download SDF |
| 分子式 | C50H60N5O10P | 分子量 | 922.01 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.0846 mL | 5.4229 mL | 10.8459 mL |
| 5 mM | 0.2169 mL | 1.0846 mL | 2.1692 mL |
| 10 mM | 0.1085 mL | 0.5423 mL | 1.0846 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Liquid Marble Photosensor
Chemphyschem 2020 Jan 3;21(1):90-98.PMID:31696651DOI:10.1002/cphc.201900949.
A liquid marble is a liquid droplet coated by a hydrophobic powder. The liquid marble does not wet adjacent surfaces and therefore can be manipulated as a dry soft body. A Belousov-Zhabotinsky (Bz) reaction is an oscillatory chemical reaction exhibiting waves of oxidation. We demonstrate how to make a photo-sensor from Bz medium liquid marbles. We insert electrodes into a liquid marble, prepared from Bz solution and coated with polyethylene powder. The electrodes record a potential difference which oscillates due to oxidation wave-fronts crossing the electrodes. When the Bz marble is illuminated by a light source, the oxidation wave-fronts are hindered and, thus, the electrical potential recorded ceases to oscillate. We characterise several types of responses of Bz marble photosensors to various stimuli, and provide explanations of the recorded activity. Bz liquid marble photosensors may find applications in the fields of liquid electronics, soft robotics and unconventional computing.
Border-zone and watershed infarctions
Front Neurol Neurosci 2012;30:181-4.PMID:22377891DOI:10.1159/000333638.
Border-zone (Bz) and watershed infarcts occur at the junction of two artery territories and are precipitated by a hemodynamic impairment although they cannot be excluded from microembolic etiology. These strokes may often be preceded by specifically precipitating circumstances that induce hypotension and/or hypovolemia (rising from a supine position, exercise, Valsalva's maneuver, administration of antihypertensive drugs, bleeding and anemia). Anterior Bz infarction occurs with a motor deficit of one or both contralateral limbs, associated with aphasia or mood disturbance. Campimetric disturbances are a constant feature of posterior Bz infarct associated with fluent aphasia and hemihypoesthesia. Subcortical and capsule-thalamic Bz infarctions often mimic lacunar syndrome due to small-vessel disease. Cerebellar Bz infarction is associated with non-specific vertigo syndrome or ataxia, while in brainstem Bz infarction patients are comatose with other signs of brainstem being compromised.
Clinical pharmacology of flumazenil
Eur J Anaesthesiol Suppl 1988;2:65-80.PMID:2842143doi
(1) Flumazenil is a highly specific benzodiazepine (Bz) antagonist. It exerts its effect by competitive interaction at the Bz receptor site. (ii) Flumazenil antagonizes all central Bz effects irrespective of its contiguity to the Bz administration. (iii) The pharmacological effect of flumazenil depends upon the number of Bz receptors that can be occupied by flumazenil according to the mass-action law. Receptor occupancy is determined by the affinity of the Bz for the receptor and the free Bz concentration near the receptor. (iv) The minimal effective dose of flumazenil is 0.2 mg. After extreme Bz overdose 1 mg may be needed. (v) The optimal dosing strategy starts with an initial dose of flumazenil 0.2 mg i.v. The administration of further low doses of 0.1 mg at 1-min intervals allows the interruption of the injection of flumazenil exactly at the stage of vigilance that is most convenient for the patient. (vi) The duration of effect depends upon the type and dose of the administered Bz, the dose of flumazenil, and the time interval between flumazenil and the Bz administration. (vii) The therapeutic or safety index is above 3000, which means that a 3000 times overdose is still tolerated.
Biochemistry of benzimidazole resistance
Acta Trop 1994 Mar;56(2-3):245-62.PMID:8203306DOI:10.1016/0001-706x(94)90066-3.
Heavy reliance on the benzimidazole (Bz) anthelmintics since their introduction in the 1960's for the control of gastrointestinal parasites of livestock has led to widespread Bz resistance in target parasite species. The BZs exert their primary action by binding to tubulin, the major protein component of microtubules. This review discusses the biochemistry of the interaction between the BZs and tubulin from mammalian and BZ-resistant and -susceptible parasite sources, exploring aspects of the selective toxicity of these drugs and examining the mechanism of Bz resistance. Although tubulin is a highly conserved protein present in both the host and the parasite, the BZs demonstrate relatively low mammalian toxicity. The selectivity of these drugs can be explained by the much higher affinity of the BZs for tubulin from the parasite at 37 degrees C compared to their affinity for tubulin from the host. This difference in affinity reflects the considerably slower rate of Bz dissociation from parasite tubulin. BZ-resistance in parasitic nematodes is characterised by a loss of high affinity BZ-parasite tubulin interactions and a corresponding increase in lower affinity interactions, although there are still significant differences between BZ-resistant parasite tubulin and tubulin from the host. These differences suggest the potential for the design of new generation BZs active against 'BZ-resistant' parasites.
Modeling the Electrophysiological Properties of the Infarct Border Zone
Front Physiol 2018 Apr 9;9:356.PMID:29686626DOI:10.3389/fphys.2018.00356.
Ventricular arrhythmias (VA) in patients with myocardial infarction (MI) are thought to be associated with structural and electrophysiological remodeling within the infarct border zone (Bz). Personalized computational models have been used to investigate the potential role of the infarct Bz in arrhythmogenesis, which still remains incompletely understood. Most recent models have relied on experimental data to assign Bz properties. However, experimental measurements vary significantly resulting in different computational representations of this region. Here, we review experimental data available in the literature to determine the most prominent properties of the infarct Bz. Computational models are then used to investigate the effect of different representations of the Bz on activation and repolarization properties, which may be associated with VA. Experimental data obtained from several animal species and patients with infarct show that Bz properties vary significantly depending on disease's stage, with the early disease stage dominated by ionic remodeling and the chronic stage by structural remodeling. In addition, our simulations show that ionic remodeling in the Bz leads to large repolarization gradients in the vicinity of the scar, which may have a significant impact on arrhythmia simulations, while structural remodeling plays a secondary role. We conclude that it is imperative to faithfully represent the properties of regions of infarction within computational models specific to the disease stage under investigation in order to conduct in silico mechanistic investigations.