2,4-Dihydroxybenzaldehyde
(Synonyms: 2,4-二羟基苯甲醛) 目录号 : GC39772
2,4-Dihydroxybenzaldehyde 是一种内源性代谢产物。
Cas No.:95-01-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2,4-Dihydroxybenzaldehyde is an endogenous metabolite.
| Cas No. | 95-01-2 | SDF | |
| 别名 | 2,4-二羟基苯甲醛 | ||
| Canonical SMILES | O=CC1=CC=C(O)C=C1O | ||
| 分子式 | C7H6O3 | 分子量 | 138.12 |
| 溶解度 | DMSO : 100 mg/mL (724.01 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.2401 mL | 36.2004 mL | 72.4008 mL |
| 5 mM | 1.448 mL | 7.2401 mL | 14.4802 mL |
| 10 mM | 0.724 mL | 3.62 mL | 7.2401 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Modification of silica nanoparticles by 2,4-Dihydroxybenzaldehyde and 5-bromosalicylaldehyde as new nanocomposites for efficient removal and preconcentration of Cu(ii) and Cd(ii) ions from water, blood, and fish muscles
RSC Adv 2022 Jul 1;12(30):19209-19224.PMID:35865597DOI:10.1039/d2ra03177a.
Herein, silica nanoparticles were modified by 2,4-Dihydroxybenzaldehyde and 5-bromosalicylaldehyde to produce new nanocomposites which were abbreviated as N1 and N2, respectively. The synthesized nanocomposites were used for efficient removal and preconcentration of Cu(ii) and Cd(ii) ions from water, blood, and fish muscles. FE-SEM, FT-IR, XRD, CHN elemental analysis, and nitrogen gas sorption analyzer were used to characterize the new nanocomposites. The XRD proved that the synthesized oxide is cristobalite with an average crystallite size of 54.80 nm. Due to the formation of the C[double bond, length as m-dash]N group, the intensity of the XRD peak at 2θ = 21.9° in the N1 and N2 nanocomposites decreased significantly. The FT-IR bands, which appeared at 1603 and 1629 cm-1 in the N1 and N2 nanocomposites, are attributable to the bending vibration of C[double bond, length as m-dash]N and/or OH, respectively. Also, the FE-SEM analysis shows the morphology of the silica nanoparticles which were identified as spherical and rod-like with slight agglomeration while the N1 and N2 nanocomposites have flaky surfaces due to the formation of C[double bond, length as m-dash]N groups. The maximum Cu(ii) ion adsorption capacities of the N1 and N2 nanocomposites are 64.81 and 40.93 mg g-1, respectively. The maximum Cd(ii) ion adsorption capacities of the N1 and N2 nanocomposites are 27.39 and 26.34 mg g-1, respectively. The adsorption of Cu(ii) or Cd(ii) ions using the synthesized nanocomposites is spontaneous, chemical, exothermic, and well-matched with the Langmuir equilibrium isotherm. The recovery findings demonstrate that the preconcentration process is accurate, adaptable, and resulted in quantitative separation because % Recovery is more than 95%. Furthermore, the % RSD was less than 3.5%, indicating good reproducibility.
2,4-Dinitrophenylhydrazones of 2,4-Dihydroxybenzaldehyde, 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzophenone
Acta Crystallogr C 2004 Feb;60(Pt 2):o103-6.PMID:14767127DOI:10.1107/S0108270103027197.
In 2,4-Dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone N,N-dimethylformamide solvate [or 4-[(2,4-dinitrophenyl)hydrazonomethyl]benzene-1,3-diol N,N-dimethylformamide solvate], C(13)H(10)N(4)O(6).C(3)H(7)NO, (X), 2,4-dihydroxyacetophenone 2,4-dinitrophenylhydrazone N,N-dimethylformamide solvate (or 4-[1-[(2,4-dinitrophenyl)hydrazono]ethyl]benzene-1,3-diol N,N-dimethylformamide solvate), C(14)H(12)N(4)O(6).C(3)H(7)NO, (XI), and 2,4-dihydroxybenzophenone 2,4-dinitrophenylhydrazone N,N-dimethylacetamide solvate (or 4-[[(2,4-dinitrophenyl)hydrazono]phenylmethyl]benzene-1,3-diol N,N-dimethylacetamide solvate), C(19)H(14)N(4)O(6).C(4)H(9)NO, (XII), the molecules all lack a center of symmetry, crystallize in centrosymmetric space groups and have been observed to exhibit non-linear optical activity. In each case, the hydrazone skeleton is fairly planar, facilitated by the presence of two intramolecular hydrogen bonds and some partial N-N double-bond character. Each molecule is hydrogen bonded to one solvent molecule.
Correction: Modification of silica nanoparticles by 2,4-Dihydroxybenzaldehyde and 5-bromosalicylaldehyde as new nanocomposites for efficient removal and preconcentration of Cu(ii) and Cd(ii) ions from water, blood, and fish muscles
RSC Adv 2022 Jul 19;12(32):20762-20764.PMID:35919159DOI:10.1039/d2ra90073d.
[This corrects the article DOI: 10.1039/D2RA03177A.].
Rapid, selective, direct and derivative spectrophotometric determination of titanium with 2,4-Dihydroxybenzaldehyde isonicotinoyl hydrazone
Talanta 1996 Apr;43(4):551-8.PMID:18966518DOI:10.1016/0039-9140(95)01766-6.
A simple and sensitive spectrophotometric method is developed for the determination of titanium in aqueous medium. The metal ion forms a reddish brown coloured complex with 2,4-Dihydroxybenzaldehyde isonicotinoyl hydrazone (2,4-DHBINH) in the pH range 1-7. The complex shows two absorption maxima, one at 430 nm and the other at 500 nm. The reagent shows appreciable absorbance of 430 nm and negligible absorbance at 500 nm at pH 1.5. Beer's law is obeyed in the range 0.09 to 2.15 mug ml(-1) of titanium(IV). The molar absorptivity and the Sandell's sensitivity of the method are 1.35 x 10(4) 1 mol(-1) cm(-1) and 0.0049 mug cm(-2), respectively. A method for the determination of titanium by first-order derivative spectrophotometry is also proposed. The methods have been employed successfully for the determination of titanium in several alloy and steel samples.
Total Synthesis of (-)-Peniphenone A
J Org Chem 2018 Jul 6;83(13):7049-7059.PMID:29480005DOI:10.1021/acs.joc.7b03231.
The asymmetric total synthesis of the polyketide benzannulated spiroketal natural product, (-)-peniphenone A, is reported. The key reaction in the synthesis involved sp3-sp2 Negishi cross-coupling between a chiral organozinc species and an aryl bromide to construct the challenging α-chiral β-aryl carbonyl motif present in the natural product. Access to the spiroketal possessing the correct stereochemistry was facilitated by an unusual thermodynamic resolution at C10. The synthesis was achieved in 14 steps (longest linear sequence) from commercially available 2,4-Dihydroxybenzaldehyde in 6% overall yield. Investigations into a parallel approach required extension of Krische's enantioselective hydrogen-mediated C-C coupling to α-substituted alcohols and oxetane ring-opening with an aryllithium for assembly of the polyketide domain. These studies provide a useful foundation for further work toward the natural product family, members of which demonstrate significant activity against M. tuberculosis and offer continuing inspiration for the development of efficient new chemical methods.