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2-Amino-5-bromo-benzonitrile Sale

(Synonyms: 2-氨基-5-溴苯甲腈) 目录号 : GC46532

A heterocyclic building block

2-Amino-5-bromo-benzonitrile Chemical Structure

Cas No.:39263-32-6

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500 mg
¥428.00
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1 g
¥686.00
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产品描述

2-Amino-5-bromo-benzonitrile is a heterocyclic building block.1,2 It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.

1.Primik, M.F., GÖschl, S., Jakupec, M.A., et al.Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligandsInorg. Chem.49(23)11084-11095(2010) 2.Renhowe, P.A., Pecchi, S., Shafer, C.M., et al.Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A novel class of receptor tyrosine kinase inhibitorsJ. Med. Chem.52(2)278-292(2009)

Chemical Properties

Cas No. 39263-32-6 SDF
别名 2-氨基-5-溴苯甲腈
Canonical SMILES NC1=C(C#N)C=C(Br)C=C1
分子式 C7H5BrN2 分子量 197
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 5.0761 mL 25.3807 mL 50.7614 mL
5 mM 1.0152 mL 5.0761 mL 10.1523 mL
10 mM 0.5076 mL 2.5381 mL 5.0761 mL
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Research Update

Metabolism of diethyl 4-[(4-bromo-2-cyanophenyl)-carbamoyl]benzylphosphonate in the rat

Xenobiotica 1996 Aug;26(8):853-61.PMID:8879149DOI:10.3109/00498259609046755

1. The metabolism of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886), an antilipidaemic agent, was evaluated in the rat. 2. 14C-NO-1886 was dosed orally to rats (3 mg/kg) and within 24 h after dosing, 27.9 +/- 2.1 and 63.5 +/- 4.2% of the administered radioactivity was recovered from urine and faeces respectively. 3. The metabolite M-2 was isolated from the urine and faeces, and two other metabolites, M-3 and M-5, were isolated from the urine. Two of them were identified as ethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (M-2) and 4-[(diethoxy-phosphoryl)methyl)]benzoic acid (M-3), and the other one was considered to be 2-amino-5-bromo-3-cyanobenzene sulphate (M-5) by ms and nmr spectrometry. 4. The major metabolic pathway of NO-1886 was found to be mono-hydrolysis of the diethyl phosphonate. It was also considered that M-5 may have been formed in vivo via 2-Amino-5-bromo-benzonitrile (M-1) and 2-amino-5-bromo-3-hydroxybenzonitrile (M-4).