2-deoxy-D-Glucose-6-phosphate (sodium salt)
(Synonyms: 2-脱氧-D-葡萄糖-6-磷酸钠盐,2-Deoxyglucose-6-phosphate) 目录号 : GC19427A 2-deoxyglucose derivative
Cas No.:33068-19-8
Sample solution is provided at 25 µL, 10mM.
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2-deoxy-D-Glucose is a synthetic analog of glucose used in cell metabolism and cancer research.[1] 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.[2] However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.
Reference
[1]. Kang, H.T., and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic Life Sciences 78(12), 1392-1399 (2006).
[2]. Urakami, K., Zangiacomi, V., Yamaguchi, K., et al. Impact of 2-deoxy-D-glucose on the target metabolite profile of a human endometrial cancer cell line Biomed.Res. 34(5), 221-229 (2013)
| Cas No. | 33068-19-8 | SDF | |
| 别名 | 2-脱氧-D-葡萄糖-6-磷酸钠盐,2-Deoxyglucose-6-phosphate | ||
| 化学名 | 6-(dihydrogen phosphate) 2-deoxy-D-arabino-hexose, monosodium salt | ||
| Canonical SMILES | O=CC[C@@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O.[Na+] | ||
| 分子式 | C6H12O8P • Na | 分子量 | 266.1 |
| 溶解度 | 10 mg/ml in PBS (pH 7.2) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.758 mL | 18.7899 mL | 37.5799 mL |
| 5 mM | 0.7516 mL | 3.758 mL | 7.516 mL |
| 10 mM | 0.3758 mL | 1.879 mL | 3.758 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet