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2-heptyl-3-hydroxy-4(1H)-Quinolone Sale

(Synonyms: 2-庚基-3-羟基-4(1H)-喹啉酮,PQS, Pseudomonas Quinolone Signal) 目录号 : GC45912

A bacterial quorum-sensing signaling molecule

2-heptyl-3-hydroxy-4(1H)-Quinolone Chemical Structure

Cas No.:108985-27-9

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5mg
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25mg
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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

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Description

2-heptyl-3-hydroxy-4(1H)-Quinolone is a quorum-sensing signaling molecule produced by P. aeruginosa in response to increasing cell density.[1] It increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay). 2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) increases secretion of the metabolite pyocyanin and the lectin PA-IL, as well as increases biofilm production in P. aeruginosa populations.[2] It also reduces iron levels in P. aeruginosa growth media when used at a concentration of 40 µM and acts as an iron chelator in a Fe(III)-sulfate solution.[3]

Reference:
[1]. Pesci, E.C., Milbank, J.B.J., Pearson, J.P., et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96(20), 11229-11234 (1999).
[2]. Diggle, S.P., Winzer, K., Chhabra, S.R., et al. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol. Microbiol. 50(1), 29-43 (2003).
[3]. Bredenbruch, F., Geffers, R., Nimtz, M., et al. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ. Microbiol. 8(8), 1318-1329 (2006).

化学性质

Cas No. 108985-27-9 SDF
别名 2-庚基-3-羟基-4(1H)-喹啉酮,PQS, Pseudomonas Quinolone Signal
化学名 2-heptyl-3-hydroxy-4(1H)-quinolinone
Canonical SMILES OC1=C(CCCCCCC)NC2=CC=CC=C2C1=O
分子式 C16H21NO2 分子量 259.3
溶解度 Soluble in methanol 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.8565 mL 19.2827 mL 38.5654 mL
5 mM 0.7713 mL 3.8565 mL 7.7131 mL
10 mM 0.3857 mL 1.9283 mL 3.8565 mL
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