Home>>Signaling Pathways>> Immunology/Inflammation>> iNOS>>2-Imino-4-methylpiperidine (acetate)

2-Imino-4-methylpiperidine (acetate) Sale

(Synonyms: 2-亚氨基-4-甲基哌啶乙酸酯) 目录号 : GC17084

A potent, general NOS inhibitor

2-Imino-4-methylpiperidine (acetate) Chemical Structure

Cas No.:165383-72-2

规格 价格 库存 购买数量
5mg
¥523.00
现货
10mg
¥936.00
现货
25mg
¥2,062.00
现货
50mg
¥2,840.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

2-Imino-4-methylpiperidine (acetate) is a potent NOS inhibitor [1]

Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in endothelium-dependent vascular relaxation, cell-to-cell communication, and cytotoxicity associated with phagocytic cells. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS [1].

2-Imino-4-methylpiperidine (acetate) is a 2-iminopiperidine class of NOS inhibitor. In the presence of a final L-arginine concentration of 30 μM, 2-Imino-4-methylpiperidine inhibited human iNOS, eNOS, and nNOS with IC50 values of 0.1, 1.1, and 0.2 μM, respectively. 2-Imino-4-methylpiperidine exhibited 9-fold and 1-fold selectivity for iNOS compared to eNOS and nNOS, respectively [1].

In LPS-treated rats, 2-Imino-4-methylpiperidine (10 mg/kg, po) inhibited plasma nitrite levels by 87%.

Reference:
[1].  Webber RK, Metz S, Moore WM, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101.

Chemical Properties

Cas No. 165383-72-2 SDF
别名 2-亚氨基-4-甲基哌啶乙酸酯
化学名 3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate
Canonical SMILES CC1CCN=C(N)C1.CC([O-])=O
分子式 C6H12N2 · C2H3O2 分子量 171.2
溶解度 ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 5.8411 mL 29.2056 mL 58.4112 mL
5 mM 1.1682 mL 5.8411 mL 11.6822 mL
10 mM 0.5841 mL 2.9206 mL 5.8411 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置