2-Methylbutyrylglycine
(Synonyms: N-(2-甲基-1-氧代丁基)-甘氨酸) 目录号 : GC49840
A metabolite of isoleucine
Cas No.:52320-67-9
Sample solution is provided at 25 µL, 10mM.
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2-Methylbutyrylglycine is a metabolite of the essential amino acid L-isoleucine.1,2 It is produced by hydrolysis of the L-isoleucine catabolic intermediate (S)-2-methylbutyryl-CoA, which accumulates when the activity of 2-methylbutyryl-CoA dehydrogenase is deficient. 2-Methylbutyrylglycine (0.5-5 mM) induces the formation of thiobarbituric acid reactive substances (TBARS) in isolated rat cerebral cortex.3 Elevated levels of 2-methylbutyrylglycine are associated with 2-methylbutyryl-CoA dehydrogenase deficiency (2-MBCDD), also known as short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency.1,2
1.Gibson, K.M., Burlingame, T.G., Hogema, B., et al.2-Methylbutyryl-coenzyme A dehydrogenase deficiency: A new inborn error of L-isoleucine metabolismPediatr. Res.47(6)830-833(2000) 2.Fong, B.M.-W., Tam, S., and Leung, S.-Y.Quantification of acylglycines in human urine by HPLC electrospray ionization-tandem mass spectrometry and the establishment of pediatric reference interval in local ChineseTalanta88193-200(2012) 3.Knebel, L.A., Zanatta, Â., Tonin, A.M., et al.2-Methylbutyrylglycine induces lipid oxidative damage and decreases the antioxidant defenses in rat brainBrain Res.147874-82(2012)
| Cas No. | 52320-67-9 | SDF | Download SDF |
| 别名 | N-(2-甲基-1-氧代丁基)-甘氨酸 | ||
| Canonical SMILES | O=C(CNC(C(CC)C)=O)O | ||
| 分子式 | C7H13NO3 | 分子量 | 159.2 |
| 溶解度 | DMSO : 100 mg/mL (628.22 mM; Need ultrasonic) | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.2814 mL | 31.407 mL | 62.8141 mL |
| 5 mM | 1.2563 mL | 6.2814 mL | 12.5628 mL |
| 10 mM | 0.6281 mL | 3.1407 mL | 6.2814 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet