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20-HETE-d6

(Synonyms: 20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6) 目录号 : GC46525

An internal standard for the quantification of 20-HETE

20-HETE-d6 Chemical Structure

Cas No.:2548939-89-3

规格 价格 库存 购买数量
25 μg
¥2,536.00
现货
50 μg
¥4,814.00
现货
100 μg
¥9,131.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

20-HETE-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.1 In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.2 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.3

1.McGiff, J.C., and Quilley, J.20-HETE and the kidney: Resolution of old problems and new beginningsAm. J. Physiol.277(3 Pt 2)R607-R623(1999) 2.Gebremedhin, D., Lange, A.R., Lowry, T.F., et al.Production of 20-HETE and its role in autoregulation of cerebral blood flowCirc. Res.87(1)60-65(2000) 3.Prakash, C., Zhang, J.Y., Falck, J.R., et al.20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urineBiochem. Biophys. Res. Commun.185(2)728-733(1992)

化学性质

Cas No. 2548939-89-3 SDF
别名 20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6
Canonical SMILES OC([2H])([2H])C([2H])([2H])C([2H])([2H])CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
分子式 C20H26D6O3 分子量 326.5
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 500 μg/ml 储存条件 Store at -20°C,protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0628 mL 15.3139 mL 30.6279 mL
5 mM 0.6126 mL 3.0628 mL 6.1256 mL
10 mM 0.3063 mL 1.5314 mL 3.0628 mL
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