21-Deoxycortisone
(Synonyms: 17α-羟基孕甾-4-烯-3,11,20-三酮) 目录号 : GC52083
A corticosteroid metabolite of 11-keto progesterone
Cas No.:1882-82-2
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone.1 It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be produced via oxidation of 21-deoxycortisol by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.2
1.van Rooyen, D., Yadav, R., Scott, E.E., et al.CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathwayJ. Steroid Biochem. Mol. Biol.199105614(2020) 2.Saisho, S., Shimozawa, K., and Yata, J.Changes of several adrenal δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiencyHorm. Res.33(1)27-34(1990)
Cas No. | 1882-82-2 | SDF | Download SDF |
别名 | 17α-羟基孕甾-4-烯-3,11,20-三酮 | ||
Canonical SMILES | C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(CC4)=O)C | ||
分子式 | C21H28O4 | 分子量 | 344.5 |
溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | 储存条件 | -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg |
1 mM | 2.9028 mL | 14.5138 mL | 29.0276 mL |
5 mM | 0.5806 mL | 2.9028 mL | 5.8055 mL |
10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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