(2S,3R,4S)-4-Hydroxyisoleucine
(Synonyms: 4-羟基异亮氨酸,(2S,3R,4S)-4-Hydroxy-L-isoleucine) 目录号 : GC38874
An amino acid with antidiabetic activity
Cas No.:55399-93-4
Sample solution is provided at 25 µL, 10mM.
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4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity.1,2,3 It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.1 In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin when administered at 25 mg/kg.2 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.3
1.Broca, C., Manteghetti, M., Gross, R., et al.4-Hydroxyisoleucine: Effects of synthetic and natural analogues on insulin secretionEur. J. Pharmacol.390(3)339-345(2000) 2.Broca, C., Breil, V., Cruciani-Guglielmacci, C., et al.Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in ratAm. J. Physiol. Endocrinol. Metab.287(3)E463-E471(2004) 3.Haeri, M.R., Limaki, H.K., White, C.J., et al.Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic ratsPhytomedicine19(7)571-574(2012)
| Cas No. | 55399-93-4 | SDF | |
| 别名 | 4-羟基异亮氨酸,(2S,3R,4S)-4-Hydroxy-L-isoleucine | ||
| Canonical SMILES | O[C@@H](C)[C@H](C)[C@H](N)C(O)=O | ||
| 分子式 | C6H13NO3 | 分子量 | 147.17 |
| 溶解度 | Water: 125 mg/mL (849.36 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL |
| 5 mM | 1.359 mL | 6.7949 mL | 13.5897 mL |
| 10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet