3,4'-Dihydroxyflavone
(Synonyms: 3,4'-二羟基黄酮,3,4'-DHF) 目录号 : GC34450
A synthetic flavonoid with diverse biological activities
Cas No.:14919-49-4
Sample solution is provided at 25 µL, 10mM.
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3',4'-Dihydroxyflavone is a synthetic flavonoid that has diverse biological activities.1,2,3,4 It inhibits tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.23 and 0.17 ?M for the human enzymes, respectively).1 3',4'-Dihydroxyflavone is active against L. donovani, T. brucei, and T. cruzi with IC50 values of 2, 1.1, and 10.1 ?g/ml, respectively.2 It induces apoptosis in and inhibits migration of GL15 glioblastoma cells when used at a concentration of 50 ?M.3 3',4'-Dihydroxyflavone (5 mg/kg) prevents LPS-induced increases in brain levels of COX-2 and inducible nitric oxide synthase (iNOS) in a mouse model of neuroinflammation.4
1.Narwal, M., Koivunen, J., Haikarainen, T., et al.Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivityJ. Med. Chem.56(20)7880-7889(2013) 2.Tasdemir, D., Kaiser, M., Brun, R., et al.Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studiesAntimicrob. Agents Chemother.50(4)1352-1364(2006) 3.Santos, B.L., Oliveira, M.N., Coelho, P.L.C., et al.Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expressionChem. Biol. Interact.242123-138(2015) 4.Kim, N., Yoo, H.-S., Ju, Y.-J., et al.Synthetic 3',4'-dihydroxyflavone exerts anti-neuroinflammatory effects in BV2 microglia and a mouse modelBiomol. Ther. (Seoul)26(2)210-217(2018)
| Cas No. | 14919-49-4 | SDF | |
| 别名 | 3,4'-二羟基黄酮,3,4'-DHF | ||
| Canonical SMILES | O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C1C=CC=C3 | ||
| 分子式 | C15H10O4 | 分子量 | 254.24 |
| 溶解度 | DMSO : ≥ 155 mg/mL (609.66 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL |
| 5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet