3,8’-Biapigenin
(Synonyms: I3,II8-Biapigenin, 3,8\-Biapigenin) 目录号 : GC49169
A biflavonoid with diverse biological activities
Cas No.:101140-06-1
Sample solution is provided at 25 µL, 10mM.
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3,8’-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities.1,2,3,4,5 It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM.2 3,8’-Biapigenin inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively).3 It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 µM.4 3,8’-Biapigenin (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats.5
1.Weng, J.-K., and Noel, J.P.Chemodiversity in Selaginella: A reference system for parallel and convergent metabolic evolution in terrestrial plantsFront. Plant Sci.4119(2013) 2.Nguyen, P.-H., Ji, D.-J., Han, Y.-R., et al.Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effectsBioorg. Med. Chem.23(13)3730-3737(2015) 3.Obach, R.S.Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depressionJ. Pharmacol. Exp. Ther.294(1)88-95(2000) 4.Silva, B., Oliveira, P.J., Dias, A.S., et al.Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insultsNeurotox. Res.13(3-4)265-279(2008) 5.Zduni?, G., Go?evac, D., Milenkovi?, M., et al.Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in ratsPhytother. Res.23(11)1559-1564(2009)
| Cas No. | 101140-06-1 | SDF | |
| 别名 | I3,II8-Biapigenin, 3,8\-Biapigenin | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=C(C5=CC=C(O)C=C5)OC6=C(C(O)=CC(O)=C6)C4=O | ||
| 分子式 | C30H18O10 | 分子量 | 538.5 |
| 溶解度 | DMSO : 50 mg/mL (92.86 mM; Need ultrasonic) | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.857 mL | 9.2851 mL | 18.5701 mL |
| 5 mM | 0.3714 mL | 1.857 mL | 3.714 mL |
| 10 mM | 0.1857 mL | 0.9285 mL | 1.857 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet