3-O-Methylquercetin
(Synonyms: 3-O-甲基槲皮素) 目录号 : GC60024
A flavone with diverse biological activities
Cas No.:1486-70-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-O-methyl Quercetin is a flavone that has been found in C. balchaschensis and has diverse biological activities.1,2,3,4 It is an inhibitor of β-secretase (IC50 = 6.5 ?M).1 It scavenges DPPH radicals and superoxide anions in cell-free assays (IC50s = 14.17 and 17.39 ?M, respectively), as well as inhibits lipid peroxidation and hydrogen peroxide-induced neuronal cell death in primary rat cortical cells (IC50s = 19 and 3.5 ?M, respectively).2 3-O-methyl Quercetin inhibits poliovirus RNA synthesis in infected HeLa cells when used at concentrations of 2 and 20 ?g/ml.3 It also inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 3.8 ?M) and reduces LPS-induced increases in the levels of inducible nitric oxide synthase (iNOS) in BV-2 microglia.4
1.Zhumanova, K., Lee, G., Baiseitova, A., et al.Inhibitory mechanism of O-methylated quercetins, highly potent β-secretase inhibitors isolated from Caragana balchaschensis (Kom.) PojarkJ. Ethnopharmacol.272113936(2021) 2.Kim, S.H., Kumar, C.N., Kim, H.J., et al.Glucose-containing flavones—their synthesis and antioxidant and neuroprotective activitiesBioorg. Med. Chem. Lett.19(21)6009-6013(2009) 3.Castrillo, J.L., and Carrasco, L.Action of 3-methylquercetin on poliovirus RNA replicationJ. Virol.61(10)3319-3321(1987) 4.Kim, J.Y., Lim, H.J., and Ryu, J.-H.In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescensBioorg. Med. Chem. Lett.18(4)1511-1514(2008)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.162 mL | 15.8098 mL | 31.6196 mL |
| 5 mM | 0.6324 mL | 3.162 mL | 6.3239 mL |
| 10 mM | 0.3162 mL | 1.581 mL | 3.162 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。