4-Acetamidobenzenesulfonamide
(Synonyms: 对乙酰胺基苯磺酰胺) 目录号 : GC49337
A metabolite of asulam and sulfanilamide
Cas No.:121-61-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4-Acetamidobenzenesulfonamide is a metabolite of the herbicide asulam and the sulfonamide antibiotic sulfanilamide .1,2,3 It is formed from asulam by conversion to sulfanilamide via intestinal microflora, followed by N4-acetylation in the liver. 4-Acetamidobenzenesulfonamide inhibits carbonic anhydrase II (CAII), CAIX, and CAXII (Kis = 246, 135, and 49 nM, respectively, for the human enzymes).4 It has also been used in the synthesis of compounds with antibacterial activity.5
1.Heijbroek, W.M., Muggleton, D.F., and Parke, D.V.Metabolism of the carbamate herbicide, asulam, in the ratXenobiotica14(3)235-247(1984) 2.Okumura, F., Ueda, O., Kitamura, S., et al.N-acetylation and N-formylation of carcinogenic arylamines and related compounds in dogsCarcinogenesis16(1)71-76(1995) 3.Olsen, H., and MØrland, J.Sulfonamide acetylation in isolated rat liver cellsActa Pharmacol. Toxicol. (Copenh)49(2)102-109(1981) 4.Ozensoy, O., Puccetti, L., Fasolis, G., et al.Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamidesBioorg. Med. Chem. Lett.15(21)4862-4866(2005) 5.Wang, X.-L., Wan, K., and Zhou, C.-H.Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activitiesEur. J. Med. Chem.45(10)4631-4639(2010)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.6685 mL | 23.3427 mL | 46.6853 mL |
| 5 mM | 0.9337 mL | 4.6685 mL | 9.3371 mL |
| 10 mM | 0.4669 mL | 2.3343 mL | 4.6685 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。