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Δ4-Dafachronic Acid

(Synonyms: 3-keto-4-Cholestenoic Acid) 目录号 : GC17515

A DAF-12 ligand that controls C. elegans development and lifespan

Δ4-Dafachronic Acid Chemical Structure

Cas No.:23017-97-2

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产品描述

Δ4-Dafachronic acid is a DAF-12 activator.

Steroid hormone dafachronic acid (DA) has been identified to regulate dauer formation and lifespan in Caenorhabditis elegans via binding to the nuclear receptor DAF-12. DAF-12, an orphan nuclear hormone receptor, regulates dauer larva diapause, reproductive development, fat metabolism, as well as life cycle/longevity in C. elegans. In addition, DAF-12 is needed for entry into dauer by acting as a transcriptional repressor of target genes that favor reproductive development when it is not bound to ligand.

In vitro: Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone acting as a ligand of DAF-12. In a previous study, it was found that there was no significant increase in the Δ4- and Δ4-dafachronic acid concentration in the long-lived glp-1 mutant, nor in the mutants defective in dauer formation [1]. Another previous study provided insights into the molecular interface between DA and IIS pathways and suggested that Δ4- and Δ7-dafachronic acid pathways had unique as well as overlapping biological functions in the control of development and lifespan [2].

In vivo: Up to now, there is no animal in vivo study reported for Δ4-Dafachronic acid.

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Li TM et al.  No Significant Increase in the Δ4- and Δ7-Dafachronic Acid Concentration in the Long-Lived glp-1 Mutant, nor in the Mutants Defective in Dauer Formation. G3 (Bethesda). 2015 May 12;5(7):1473-9.
[2] Dumas, K. J.,Guo, C.,Wang, X., et al. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev.Biol. 340(2), 605-612 (2010).

Chemical Properties

Cas No. 23017-97-2 SDF
别名 3-keto-4-Cholestenoic Acid
化学名 3-oxo-cholest-4-en-26-oic acid
Canonical SMILES O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@@H](CCCC(C)C(O)=O)C)=C1
分子式 C27H42O3 分子量 414.6
溶解度 ≤12.5mg/ml in ethanol;2.5mg/ml in DMSO;5mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mM 2.412 mL 12.0598 mL 24.1196 mL
5 mM 0.4824 mL 2.412 mL 4.8239 mL
10 mM 0.2412 mL 1.206 mL 2.412 mL
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