4-hydroxy Estrone
(Synonyms: 4-羟基雌酮; 4-OHE1) 目录号 : GC48824A metabolite of estrone
Cas No.:3131-23-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone .1 It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells.2 It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 values of 30 and 38 µM, respectively.3
1.Cribb, A.E., Knight, M.J., Dryer, D., et al.Role of polymorphic human cytochrome P450 enzymes in estrone oxidationCancer Epidemiol. Biomarkers Prev.15(3)551-558(2006) 2.Choi, H.J., Lee, A.J., Kang, K.S., et al.4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damageSci. Rep.10(1)7283(2020) 3.Seeger, H., Huober, J., Wallwiener, D., et al.Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifenHorm. Metab. Res.36(5)277-280(2004)
| Cas No. | 3131-23-5 | SDF | |
| 别名 | 4-羟基雌酮; 4-OHE1 | ||
| Canonical SMILES | C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3 | ||
| 分子式 | C18H22O3 | 分子量 | 286.4 |
| 溶解度 | DMSO: slightly soluble,Ethanol: slightly, sonicated | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4916 mL | 17.4581 mL | 34.9162 mL |
| 5 mM | 0.6983 mL | 3.4916 mL | 6.9832 mL |
| 10 mM | 0.3492 mL | 1.7458 mL | 3.4916 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Occurrence, seasonal variation and risk evaluation of selected endocrine disrupting compounds and their transformation products in Jiulong river and estuary, China
Mar Pollut Bull 2019 Aug;145:370-376.PMID:31590799DOI:10.1016/j.marpolbul.2019.05.016.
In the present study, 13 endocrine disrupting compounds (EDCs) and their transformation products (TPs) were monitored in Jiulong River and its estuary, China in different seasons. The analytes included antimicrobials [triclosan (TCS) and triclocarbon (TCC)]; estrogens [estrone (E1), estradiol (E2), estriol (E3) and ethinylestradiol (EE2)]; alkylphenol ethoxylates [4-n-nonylphenol (NP) and 4-n-octylphenol (OP)] and the TPs [methyl triclosan (MeTCS), carbanilide (NCC), dichlorocarbanilide, 4-hydroxy Estrone (4-OH E1) and 4-hydroxy estradiol (4-OH E2)]. A significant seasonal variation was observed for most EDCs. Approximately, 79% of the total E2 residues were detected in the normal season in comparison with the wet season to indicate recalcitrant behavior of E2 during the normal season. Risk assessment revealed that E2 was most potent among the EDCs to cause highest risk to both vertebrate and invertebrate aquatic species, whereas, E1, EE2, MeTCS and TCS also showed relatively high risk for some surface water aquatic species.