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4-hydroxy Nonenal-d3

(Synonyms: 4-HNE-d3) 目录号 : GC46661

An internal standard for the quantification of 4-hydroxy nonenal

4-hydroxy Nonenal-d3 Chemical Structure

Cas No.:148706-06-3

规格 价格 库存
50 μg
¥720.00
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100 μg
¥1,371.00
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500 μg
¥5,756.00
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1 mg
¥10,073.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

4-hydroxy Nonenal-d3 (4-HNF-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE by GC- or LC-mass spectrometry. 4-HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.1,2 4-HNE is widely used as a marker of lipid peroxidation.2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.2

1.Pryor, W.A., and Porter, N.A.Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acidsFree Radical Biology & Medicine8541-543(1990) 2.Esterbauer, H., Schaur, R.J., and Zoliner, H.Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydesFree Radical Biology & Medicine1181-128(1991) 3.Sodum, R.S., and Chung, F.L.1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenalCancer Research48320-323(1988)

Chemical Properties

Cas No. 148706-06-3 SDF
别名 4-HNE-d3
Canonical SMILES [H]C(/C=C/C(O)CCCCC([2H])([2H])[2H])=O
分子式 C9H13D3O2 分子量 159.2
溶解度 DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): .5 mg/ml 储存条件 Store at -80°C, protect from light
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1 mg 5 mg 10 mg
1 mM 6.2814 mL 31.407 mL 62.8141 mL
5 mM 1.2563 mL 6.2814 mL 12.5628 mL
10 mM 0.6281 mL 3.1407 mL 6.2814 mL
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