4-hydroxy Nonenal Glutathione-d3 (trifluoroacetate salt)
(Synonyms: 4HNEGSHd3) 目录号 : GC46659
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
4-
1.Pryor, W.A., and Porter, N.A.Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acidsFree Radical Biology & Medicine8541-543(1990) 2.Esterbauer, H., Schaur, R.J., and Zoliner, H.Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydesFree Radical Biology & Medicine1181-128(1991) 3.Siems, W., Crifo, C., Capuozzo, E., et al.Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytesArchives of Biochemistry and Biophysics503248-252(2010) 4.Laurent, A., Alary, J., Debrauwer, L., et al.Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidationChemical Research in Toxicology12887-894(1999) 5.Siems, W., and Grune, T.Intracellular metabolism of 4-hydroxynonenalMol.Aspects Med.24167-175(2003) 6.Alary, J., Fernandez, Y., Debrauwer, L., et al.Identification of intermediate pathways of 4-hydroxynonenal metabolism in the ratChemical Research in Toxicology16320-327(2003) 7.VÖlkel, W., Alvarez-SÁnchez, R., Weick, I., et al.Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in ratsFree Radical Biology & Medicine381526-1536(2005) 8.King, A.O., Corley, E.G., Anderson, R.K., et al.An efficient synthesis of LTD4 antagonist L-699,392The Journal of Organic Chemistry583731-3735(1993) 9.Falletti, O., Cadet, J., Favier, A., et al.Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cellsFree Radical Biology & Medicine421258-1269(2007)
Cas No. | N/A | SDF | |
别名 | 4HNEGSHd3 | ||
Canonical SMILES | O=C(NCC(O)=O)[C@H](CS[C@H]1CC(O)OC1CCCCC([2H])([2H])[2H])NC(CC[C@@H](N)C(O)=O)=O.FC(F)(C(O)=O)F | ||
分子式 | C19H30D3N3O8S.CF3COOH | 分子量 | 580.6 |
溶解度 | Water: 10 mg/ml | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.7224 mL | 8.6118 mL | 17.2236 mL |
5 mM | 0.3445 mL | 1.7224 mL | 3.4447 mL |
10 mM | 0.1722 mL | 0.8612 mL | 1.7224 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet