4-Hydroxyphenylacetic acid
(Synonyms: 4-羟基苯乙酸) 目录号 : GC33815
A phenolic acid with anti-inflammatory and anti-steatotic activities
Cas No.:156-38-7
Sample solution is provided at 25 µL, 10mM.
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4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory and anti-steatotic activities.1,2 It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.3,4,5 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury.1 It reverses hepatic steatosis in a mouse model of high-fat diet-induced obesity when administered via a subcutaneous implant at a dose of 350 ?g/day for two weeks.2 Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet.3 Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.6
1.Liu, Z., Xi, R., Zhang, Z., et al.4-hydroxyphenylacetic acid attenuated inflammation and edema via suppressing HIF-1α in seawater aspiration-induced lung injury in ratsInt. J. Mol. Sci.15(7)12861-12884(2014) 2.Osborn, L.J., Schultz, K., Massey, W., et al.A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosisProc. Natl. Acad. Sci. USA119(48)e2202934119(2022) 3.Zeng, Y., Lin, Y., Li, L., et al.Targeted metabolomics for the quantitative measurement of 9 gut microbiota-host co-metabolites in rat serum, urine and feces by liquid chromatography-tandem mass spectrometryJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.1110-1111133-143(2019) 4.Kim, D.-H., Jung, E.-A., Sohng, I.-S., et al.Intestinal bacterial metabolism of flavonoids and its relation to some biological activitiesArch. Pharm. Res.21(1)17-23(1998) 5.Chen, H., and Sang, S.Biotransformation of tea polyphenols by gut microbiotaJ. Funct. Foods726-42(2014) 6.Nishiumi, S., Shinohara, M., Ikeda, A., et al.Serum metabolomics as a novel diagnostic approach for pancreatic cancerMetabolomics6(4)518–528(2010)
| Cas No. | 156-38-7 | SDF | |
| 别名 | 4-羟基苯乙酸 | ||
| Canonical SMILES | O=C(O)CC1=CC=C(O)C=C1 | ||
| 分子式 | C8H8O3 | 分子量 | 152.15 |
| 溶解度 | DMSO : ≥ 100 mg/mL (657.25 mM) | 储存条件 | Store at -20°C, stored under nitrogen |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.5725 mL | 32.8623 mL | 65.7246 mL |
| 5 mM | 1.3145 mL | 6.5725 mL | 13.1449 mL |
| 10 mM | 0.6572 mL | 3.2862 mL | 6.5725 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet