4-Methylamino antipyrine hydrochloride
(Synonyms: 安乃近杂质C) 目录号 : GC60523
An active metabolite of metamizole
Cas No.:856307-27-2
Sample solution is provided at 25 µL, 10mM.
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4-Methylaminoantipyrine is a major active metabolite of the non-opioid prodrug metamizole .1 It is formed from metamizole by non-enzymatic hydrolysis in the gastrointestinal tract.2 4-Methylaminoantipyrine (0.1 mM) inhibits production of prostaglandin E2 induced by the calcium ionophore A23187 in isolated mouse peritoneal macrophages.3 It increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia when administered at a dose of 160 ?g/paw.4 4-Methylaminoantipyrine (60, 90, and 120 mg/kg) reduces LPS-induced pyrexia in rats.5 It is also a potential impurity found in commercial preparations of metamizole.6
1.Rogosch, T., Sinning, C., Podlewski, A., et al.Novel bioactive metabolites of dipyrone (metamizol)Bioorg. Med. Chem.20(1)101-107(2012) 2.Nikolova, I., Tencheva, J., Voynikov, Y., et al.Metamizole: A review profile of a well-known “forgotten” drug. Part I: Pharmaceutical and nonclinical profileBiotechnol. Biotechnol. Equip.26(6)3329-3337(2012) 3.Brune, K., Aehringhaus, U., and Peskar, B.A.Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophagesAgents Actions14(5-6)729-734(1984) 4.Gon?alves Dos Santos, G., Vieira, W.F., Vendramini, P.H., et al.Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and κ-opioid receptors activationEur. J. Pharmacol.874173005(2020) 5.Malvar, D.d.C., Aguiar, F.A., Vaz Ade, L., et al.Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent feverBr. J. Pharmacol.171(15)3666-3679(2014) 6.Vieira, J.C., Sversut, R.A., Maciel, I.T., et al.HPLC–DAD method for simultaneous determination of dipyrone (metamizole) and caffeine in tablets and identification of major degradation product by direct infusion ESI–MSChromatographia80(3)489–495(2017)
| Cas No. | 856307-27-2 | SDF | |
| 别名 | 安乃近杂质C | ||
| Canonical SMILES | O=C1N(C2=CC=CC=C2)N(C)C(C)=C1NC.[H]Cl | ||
| 分子式 | C12H16ClN3O | 分子量 | 253.73 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9412 mL | 19.706 mL | 39.412 mL |
| 5 mM | 0.7882 mL | 3.9412 mL | 7.8824 mL |
| 10 mM | 0.3941 mL | 1.9706 mL | 3.9412 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet