5-hydroxy Tryptophol
(Synonyms: 5-羟基色醇) 目录号 : GC12829
A metabolite of tryptophan
Cas No.:154-02-9
Sample solution is provided at 25 µL, 10mM.
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5-hydroxy Tryptophol is a metabolite of tryptophan.
Tryptophan (encoded by the codon UGG) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan has an α-amino group, an α-carboxylic acid group, and a side chain indole, demonstrating it as a non-polar, aromatic amino acid. Tryptophan is critical in humans, but the body cannot synthesize it and therefore tryptophan must be obtained from the diet. Tryptophan is also found to be a precursor to the neurotransmitters serotonin and melatonin.
In vitro: In previous studies, 5-hydroxy tryptophol was identified as a metabolite of tryptophan that was formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin intermediate, 5-hydroxyindoleacetaldehyde. Moreover, depending on the tissue NAD/NADH ratio, the acetaldehyde intermediate could also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid. Therefore, the ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid could be used as a biomarker for recent alcohol consumption [1,2].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Yokoyama, M. T. and Carlson, J.R. Dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. Appl.Microbiol. 27(3), 540-548 (1974).
[2] Beck, O. ,Stephanson, N.,Btthcer, M., et al. Biomarkers to disclose recent intake of alcohol: Potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods. Alcohol & Alcoholism 42(4), 321-325 (2007).
| Cas No. | 154-02-9 | SDF | |
| 别名 | 5-羟基色醇 | ||
| 化学名 | 5-hydroxy-1H-indole-3-ethanol | ||
| Canonical SMILES | OCCC1=CNC2=C1C=C(O)C=C2 | ||
| 分子式 | C10H11NO2 | 分子量 | 177.2 |
| 溶解度 | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.6433 mL | 28.2167 mL | 56.4334 mL |
| 5 mM | 1.1287 mL | 5.6433 mL | 11.2867 mL |
| 10 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet