6α-Methylprednisolone 21-hemisuccinate sodium salt
(Synonyms: Methylprednisolone hydrogen succinate sodium) 目录号 : GC60535
A prodrug form of methylprednisolone
Cas No.:2375-03-3
Sample solution is provided at 25 µL, 10mM.
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6α-Methylprednisolone 21-hemisuccinate is a prodrug form of the synthetic glucocorticoid methylprednisolone .1 It is converted to methylprednisolone by carboxylesterase 2 (CES2).2 Nanoliposomes containing 6α-methylprednisolone 21-hemisuccinate decrease disease severity in a rat model of adjuvant-induced arthritis.3 Formulations containing 6α-methylprednisolone 21-hemisuccinate have been used as anti-inflammatory agents and immunosuppressants with indications in allergic reactions and dermatologic, renal, gastrointestinal, respiratory, and ophthalmic diseases, as well as endocrine, hematologic, and rheumatic disorders.
1.Vree, T.B., Lagerwerf, A.J., Verwey-van Wissen, C.P., et al.High-performance liquid chromatography analysis, preliminary pharmacokinetics, metabolism and renal excretion of methylprednisolone with its C6 and C20 hydroxy metabolites in multiple sclerosis patients receiving high-dose pulse therapyJ. Chromatogr. B Biomed. Sci. Appl.732(2)337-348(1999) 2.Hori, T., Jin, L., Fujii, A., et al.Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 geneXenobiotica42(7)614-623(2012) 3.Avnir, Y., Ulmansky, R., Wasserman, V., et al.Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: A novel approach to treating autoimmune arthritisArthritis Rheum.58(1)119-129(2008)
| Cas No. | 2375-03-3 | SDF | |
| 别名 | Methylprednisolone hydrogen succinate sodium | ||
| Canonical SMILES | C[C@@]12[C@](C(COC(CCC(O[Na])=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O | ||
| 分子式 | C26H33NaO8 | 分子量 | 496.53 |
| 溶解度 | DMSO: ≥ 25 mg/mL (50.35 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.014 mL | 10.0699 mL | 20.1398 mL |
| 5 mM | 0.4028 mL | 2.014 mL | 4.028 mL |
| 10 mM | 0.2014 mL | 1.007 mL | 2.014 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet