6-Acetamidohexanoic acid (Acexamic Acid)
(Synonyms: 6-乙酰氨基己酸) 目录号 : GC33549
6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate.
Cas No.:57-08-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate.
| Cas No. | 57-08-9 | SDF | |
| 别名 | 6-乙酰氨基己酸 | ||
| Canonical SMILES | O=C(O)CCCCCNC(C)=O | ||
| 分子式 | C8H15NO3 | 分子量 | 173.21 |
| 溶解度 | DMSO : ≥ 1.8 mg/mL (10.39 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.7733 mL | 28.8667 mL | 57.7334 mL |
| 5 mM | 1.1547 mL | 5.7733 mL | 11.5467 mL |
| 10 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[The production of pharmacologically active Acexamic Acid derivatives. I. The production of Acexamic Acid and its zinc salt]
Rev Med Chir Soc Med Nat Iasi 1990 Apr-Jun;94(2):381-4.PMID:2100856doi
In view of studying the pharmacological properties of zinc acexamath a simple and cheap method for the synthesis of Acexamic Acid by re-evaluating some indigenous raw materials is presented. The conversion of Acexamic Acid into the corresponding zinc salt is highly efficient by reacting this acid with zinc oxide or zinc carbonate.
[So-called refractory hypoxemia: treatment with Acexamic Acid]
Nouv Presse Med 1979 Dec 3;8(47):3899.PMID:95046doi
Acexamic Acid is currently used to avoid pulmonary fibrosis in patients treated with bleomycim. It seems to be equally effective to prevent pulmonary fibrosis in adult respiratory distress syndrome. The complications of this therapy are hypercalcemia and hypernatremia.
Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats
J Pharm Pharmacol 1990 Oct;42(10):679-84.PMID:1982137DOI:10.1111/j.2042-7158.1990.tb06558.x.
The uptake of zinc as Acexamic Acid salt in the small intestine of the anaesthetized rat was shown to be a two-phase process in normal animals. The first phase is rapid mucosal binding which satisfies the Freundlich isotherm equation and which involves about 30 per cent of the initially perfused zinc. The second phase was characterized as an apparent absorption step which obeys Michaelis-Menten and first-order combined kinetics, with the following parameters: Vm = 6.51 mg h-1; Km = 2.96 mg; ka = 0.306 h-1. In largely non-saturated conditions, an apparent global rate constant of about 2.50 h-1 was calculated. No significant interference due to endogenous zinc excretion into the small intestine was observed during the absorption period. In zinc-deficient animals, the two phases were not so well characterized. Binding was non-linear and apparent absorption efficiency was much greater at high zinc concentrations, so no evidence of saturable kinetics was found, thus confirming the hypothesis of a homeostatic zinc regulation mechanism.
Comparison of the anti-inflammatory activity of sodium acexamate and zinc acexamate in healing skin wounds in rabbits
Pharmacology 1987;34(5):296-300.PMID:3615571DOI:10.1159/000138282.
After obtaining an abscess on the inner thigh of rabbits, the resulting inflammatory area was treated with sodium acexamate and zinc acexamate (0.5 ml s.c. of a 7% w/v solution). All animals received labeled leukocytes (111In, 1 mCi, i.v.). The hyperfixation was measured by comparing the inflammatory areas. In the group treated with zinc acexamate, the regression of inflammation was highly significant (p less than 0.001) in comparison with the other groups. These results emphasize the importance of combining zinc with Acexamic Acid for healing skin wounds.
Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon
Pharm Res 1996 Aug;13(8):1154-61.PMID:8865304DOI:10.1023/a:1016095732629.
Purpose: The uptake of zinc as Acexamic Acid salt in the rat gastrointestinal tract, using an in situ static technique, was studied. Our aim was to investigate an absorption window for zinc and the uptake kinetics in the colon. Methods: To detect selectivity phenomena in zinc absorption, buffered saline solutions of zinc (50 micrograms/ ml) were perfused in stomach, whole colon and three 33-cm fractions of the small intestine (proximal, middle and distal segments). To characterize zinc uptake kinetics in whole colon, five different zinc concentrations (5, 25, 50, 150 y 250 micrograms/ml) were assayed. Zinc secreted into the gastrointestinal tract during the experiments was deducted from the uptake. Results: Zinc secretion was characterized as an apparent zero-order process for all the studied segments (mean secretion rate = 0.10 +/- 0.03 microgram/(ml x min)). The stomach exhibited little ability to absorb zinc (apparent first order rate constant = 0.17 +/- 0.07 h-1), whereas the highest transport rates were found in the last two thirds of the small intestine and colon (first order constants: 0.66 +/- 0.13 h-1, 1.00 +/- 0.06 h-1, 0.97 +/- 0.14 h-1, 0.96 +/- 0.19 h-1 for proximal, middle, distal and colon segments, respectively). Zinc uptake in the colon was characterized by means of a Michaelis-Menten and first-order combined kinetics, with the following parameters: Vm = 0.36 +/- 0.02 microgram/(ml x min), Km = 18.01 +/- 0.40 microgram /ml and Ka = 0.40 +/- 0.01 h-1. Conclusions: Zinc is preferably absorbed in the middle and distal parts of the rat gastrointestinal tract. In the colon a saturable mechanism may be involved in apparent absorption.