6-Hydroxymelatonin
(Synonyms: 苏达灭) 目录号 : GC33704
An active metabolite of melatonin
Cas No.:2208-41-5
Sample solution is provided at 25 µL, 10mM.
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6-hydroxy Melatonin is an active metabolite of melatonin .1,2,3,4,5 It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.6 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.1,2 It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 ?M).3 6-hydroxy Melatonin (10 and 100 ?M) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.4 It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.5
1.Dubocovich, M.L., Masana, M.I., Iacob, S., et al.Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptorNaunyn-Schmiedeberg's Arch. Pharmacol.355(3)365-375(1997) 2.Dubocovich, M.L.Melatonin receptors: Are there multiple subtypes?Trends Pharamacol. Sci.16(2)50-56(1995) 3.Dubocovich, M.L.Characterization of a retinal melatonin receptorJ. Pharmacol. Exp. Ther.234(2)395-401(1985) 4.Lowes, D.A., Almawash, A.M., Webster, N.R., et al.Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsisBr. J. Anaesth.107(2)193-201(2011) 5.Maharaj, D.S., Maharaj, H., Daya, S., et al.Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicityJ. Neurochem.96(1)78-81(2006) 6.H?rtter, S., Wang, X., Weigmann, H., et al.Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatoninJ. Clin. Psychopharmacol.21(2)167-174(2001)
| Cas No. | 2208-41-5 | SDF | |
| 别名 | 苏达灭 | ||
| Canonical SMILES | CC(NCCC1=CNC2=C1C=C(OC)C(O)=C2)=O | ||
| 分子式 | C13H16N2O3 | 分子量 | 248.28 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.0277 mL | 20.1386 mL | 40.2771 mL |
| 5 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL |
| 10 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet