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6-methoxy Naphthalene Acetic Acid Sale

(Synonyms: 6-甲基萘乙酸,6-MNA) 目录号 : GC16153

A non-selective COX inhibitor

6-methoxy Naphthalene Acetic Acid Chemical Structure

Cas No.:23981-47-7

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10mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

6-methoxy Naphthalene Acetic Acid is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively [1][2][3].

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, PGHS), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. COX-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].

6-methoxy Naphthalene Acetic Acid (6-MNA) is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively [1][2]. 6-MNA is a metabolite of nebumetome. 6-MNA inhibited human recombinant COX-1 and -2 with IC50 values of 70 and 20 μM, respectively [1].

References:
[1].  Barnett J, Chow J, Ives D, et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta. 1994 Nov 16;1209(1):130-9.
[2].  Johnson JL, Wimsatt J, Buckel SD, et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys. 1995 Dec 1;324(1):26-34.
[3].  Laneuville O1, Breuer DK, Dewitt DL, et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 1994 Nov;271(2):927-34.

Chemical Properties

Cas No. 23981-47-7 SDF
别名 6-甲基萘乙酸,6-MNA
化学名 6-methoxy-2-naphthaleneacetic acid
Canonical SMILES COC1=CC(C=CC(CC(O)=O)=C2)=C2C=C1
分子式 C13H12O3 分子量 216.2
溶解度 ≤55mg/ml in ethanol;24mg/ml in DMSO;25mg/ml in dimethyl formamide 储存条件 Room temperature
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 4.6253 mL 23.1267 mL 46.2535 mL
5 mM 0.9251 mL 4.6253 mL 9.2507 mL
10 mM 0.4625 mL 2.3127 mL 4.6253 mL
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