6-Methylcoumarin
(Synonyms: 6-甲基香豆素) 目录号 : GC33657
6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
Cas No.:92-48-8
Sample solution is provided at 25 µL, 10mM.
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6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion[1].
The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 ?g/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 ?g/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats[1].
[1] PA Cárdenas, et al. Braz J Pharm Sci. 2017, 53(1).
| Cas No. | 92-48-8 | SDF | |
| 别名 | 6-甲基香豆素 | ||
| Canonical SMILES | O=C1C=CC2=CC(C)=CC=C2O1 | ||
| 分子式 | C10H8O2 | 分子量 | 160.17 |
| 溶解度 | DMSO : ≥ 125 mg/mL (780.42 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.2434 mL | 31.2168 mL | 62.4337 mL |
| 5 mM | 1.2487 mL | 6.2434 mL | 12.4867 mL |
| 10 mM | 0.6243 mL | 3.1217 mL | 6.2434 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet