7α-Thiospironolactone
(Synonyms: Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL) 目录号 : GC49391
An active metabolite of spironolactone
Cas No.:38753-76-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.1 In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.2 It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.3
1.Los, L.E., Coddington, A.B., Ramjit, H.G., et al.Identification of spironolactone metabolites in plasma and target organs of guinea pigsDrug Metab. Dispos.21(6)1086-1090(1993) 2.Menard, R.H., Loriaux, D.L., Bartter, F.C., et al.The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogsSteroids31(6)771-782(1978) 3.Szabo, S., and Gagnon, M.J.The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in ratsGen. Pharmacol.14(2)269-272(1983)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6702 mL | 13.3511 mL | 26.7023 mL |
| 5 mM | 0.534 mL | 2.6702 mL | 5.3405 mL |
| 10 mM | 0.267 mL | 1.3351 mL | 2.6702 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。